Abstract
We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm3). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.
Original language | English (US) |
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Pages (from-to) | 232-235 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 845 |
Issue number | 2 |
DOIs | |
State | Published - Oct 23 1999 |
Keywords
- Acute subdural hematoma
- BAY X3702
- Ischemia
- Neuroprotection
- Rat
- Serotonin 5-HT(1A) agonist
ASJC Scopus subject areas
- Neuroscience(all)