The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat

Beat Alessandri; Eij Tsuchida; Ross M. Bullock

doi:10.1016/S0006-8993(99)01948-4

The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat

Beat Alessandri, Eij Tsuchida, Ross M. Bullock

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm³ for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm³). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	232-235
Number of pages	4
Journal	Brain research
Volume	845
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01948-4
State	Published - Oct 23 1999

Keywords

Acute subdural hematoma
BAY X3702
Ischemia
Neuroprotection
Rat
Serotonin 5-HT(1A) agonist

ASJC Scopus subject areas

Neuroscience(all)

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title = "The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat",

abstract = "We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm3). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Acute subdural hematoma, BAY X3702, Ischemia, Neuroprotection, Rat, Serotonin 5-HT(1A) agonist",

author = "Beat Alessandri and Eij Tsuchida and Bullock, {Ross M.}",

note = "Funding Information: This study was funded in part by NIH grant number NS 12578, and BAY X3702 was provided by Bayer, Troponwerke, Germany. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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AU - Bullock, Ross M.

N1 - Funding Information: This study was funded in part by NIH grant number NS 12578, and BAY X3702 was provided by Bayer, Troponwerke, Germany. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

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N2 - We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm3). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.

AB - We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm3). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.

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The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat

Abstract

Keywords

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