The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat

Beat Alessandri, Eij Tsuchida, Ross M. Bullock

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT(1A)) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 μl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01±39 and 60.8±49 mm3 for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2±33 mm3). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)232-235
Number of pages4
JournalBrain Research
Volume845
Issue number2
DOIs
StatePublished - Oct 23 1999

Keywords

  • Acute subdural hematoma
  • BAY X3702
  • Ischemia
  • Neuroprotection
  • Rat
  • Serotonin 5-HT(1A) agonist

ASJC Scopus subject areas

  • Neuroscience(all)

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