La epidemia de neuropatia en Cuba: Ocho anos de estudio y seguimiento

Translated title of the contribution: The neuropathy epidemic in Cuba: Eight years of investigation and follow-up

R. Santiesteban-Freixas, C. Serrano-Verdura, J. Gutierrez-Gil, S. Luis-Gonzalez, A. Gonzalez-Quevedo, M. Francisco-Plasencia, M. Rodriguez-Gonzalez, C. Mendoza-Santiesteban, M. Santin-Pena

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Introduction. The authors describes the past eight years, since an epidemic started in Cuba which mainly affected the nervous system, particularly the optic nerve and the peripheral nerves. It is thought to have been the biggest epidemic involving the nervous system this century, although there may be over-diagnosis. The cause is controversial but is probably nutritional imbalance with additional toxic elements also in some cases. At the present time the continuous, low, notification of new cases means that it is endemic. Development. In this paper we consider the clinical and electrophysiological aspects characteristic of the disorder, the degree of involvement, evolution, incidence and annual follow-up of cases from 1992 to date and their differential diagnosis. We describe the national programme of healthcare for control of the disease in Cuba, the measures designed to reduce the number of patients, most of the results of clinical and epidemiological studies and the possible causes. We also discuss the most likely physiopathological hypotheses.

Translated title of the contributionThe neuropathy epidemic in Cuba: Eight years of investigation and follow-up
Original languageSpanish
Pages (from-to)549-566
Number of pages18
JournalRevista de neurologia
Issue number6
StatePublished - 2000
Externally publishedYes


  • Endemic
  • Epidemic
  • Nutritional amblyopia
  • Optic atrophy
  • Peripheral neuropathy
  • Tropical neuropathy

ASJC Scopus subject areas

  • Clinical Neurology


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