The neuropathology of Acquired Immune Deficiency Syndrome

L. B. Moskowitz, G. T. Hensley, J. C. Chan, J. Gregorios, F. K. Conley

Research output: Contribution to journalArticle

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Abstract

We reviewed the neuropathologic characteristics of 52 cases of acquired immune deficiency syndrome (AIDS) at autopsy. Histologically significant neuropathologic lesions were found in 38 cases. We believed that infection was the predominant pathologic process in 26 cases; occasionally, multiple infectious agents were present. This included Toxoplasma encephalitis (n = 16), fungal abscess (n = 1), tuberculous abscess (n = 1), progressive multifocal leukoencephalopathy (n = 2), cysticercosis (n = 1), and Escherichia coli meningoencephalitis (n = 1). Microglial nodules or perivascular inflammation suggested that encephalitis was the most likely cause in five cases. In two additional cases, a primary demyelinating process that was apparently related to cytomegalovirus was present. Vascular or hypoxic diseases were present in nine cases. The findings included intracerebral hemorrhage (n = 1), subarachnoid hemorrhage (n = 2), infarction (n = 2), diffuse hypoxic changes (n = 5), cerebral edema (n = 1), and rare thromboemboli with extravasation of RBCs (n = 1). One case of primary lymphoma was observed. The CNS lesions were the proximate cause of death in 15 patients. The CNS complications of AIDS are varied and often are the major manifestation of the syndrome.

Original languageEnglish
Pages (from-to)867-872
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume108
Issue number11
StatePublished - Dec 1 1984
Externally publishedYes

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Encephalitis
Abscess
Acquired Immunodeficiency Syndrome
Progressive Multifocal Leukoencephalopathy
Cysticercosis
Meningoencephalitis
Brain Edema
Toxoplasma
Cerebral Hemorrhage
Pathologic Processes
Subarachnoid Hemorrhage
Cytomegalovirus
Infarction
Blood Vessels
Cause of Death
Autopsy
Lymphoma
Escherichia coli
Inflammation
Infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Moskowitz, L. B., Hensley, G. T., Chan, J. C., Gregorios, J., & Conley, F. K. (1984). The neuropathology of Acquired Immune Deficiency Syndrome. Archives of Pathology and Laboratory Medicine, 108(11), 867-872.

The neuropathology of Acquired Immune Deficiency Syndrome. / Moskowitz, L. B.; Hensley, G. T.; Chan, J. C.; Gregorios, J.; Conley, F. K.

In: Archives of Pathology and Laboratory Medicine, Vol. 108, No. 11, 01.12.1984, p. 867-872.

Research output: Contribution to journalArticle

Moskowitz, LB, Hensley, GT, Chan, JC, Gregorios, J & Conley, FK 1984, 'The neuropathology of Acquired Immune Deficiency Syndrome', Archives of Pathology and Laboratory Medicine, vol. 108, no. 11, pp. 867-872.
Moskowitz LB, Hensley GT, Chan JC, Gregorios J, Conley FK. The neuropathology of Acquired Immune Deficiency Syndrome. Archives of Pathology and Laboratory Medicine. 1984 Dec 1;108(11):867-872.
Moskowitz, L. B. ; Hensley, G. T. ; Chan, J. C. ; Gregorios, J. ; Conley, F. K. / The neuropathology of Acquired Immune Deficiency Syndrome. In: Archives of Pathology and Laboratory Medicine. 1984 ; Vol. 108, No. 11. pp. 867-872.
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