The neuroendocrine effects of early life trauma

Jamie L. LaPrairie, Christine M. Heim, Charles Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

This chapter summarizes available findings on the neuroendocrine effects of exposure to trauma during early development, with a focus on a role for such alterations in the increased risk of mood and anxiety disorders in adulthood. The principal components of the stress system are the hypothalamic-pituitary-adrenal (HPA) axis, the locus ceruleus-norepinephrine (LC-NE) system and the extrahypothalamic corticotropin-releasing factor (CRF) systems. In addition, increased rates of major depression, post-traumatic stress disorder (PTSD) and attention-deficit hyperactivity disorder (ADHD) have been reported in maltreated children. The relationship between early adverse experiences and the development of adult psychopathology is likely mediated by alterations in neurobiological systems involved in the regulation of stress. Findings from the research would have important implications for the development of optimized treatment strategies that directly target different neurobiological pathways involved in depression and anxiety disorders in victims of early child maltreatment.

Original languageEnglish (US)
Title of host publicationThe Impact of Early Life Trauma on Health and Disease: The Hidden Epidemic
PublisherCambridge University Press
Pages157-165
Number of pages9
ISBN (Print)9780511777042, 9780521880268
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The neuroendocrine effects of early life trauma'. Together they form a unique fingerprint.

  • Cite this

    LaPrairie, J. L., Heim, C. M., & Nemeroff, C. (2010). The neuroendocrine effects of early life trauma. In The Impact of Early Life Trauma on Health and Disease: The Hidden Epidemic (pp. 157-165). Cambridge University Press. https://doi.org/10.1017/CBO9780511777042.019