The neurobiology of urocortin

Kelly H. Skelton, Michael J. Owens, Charles B. Nemeroff

Research output: Contribution to journalReview article

122 Scopus citations

Abstract

Urocortin (UCN) is a recently isolated 40 amino acid-containing neuropeptide that is the second endogenous mammalian ligand for the corticotropin-releasing factor (CRF) receptors. While UCN and CRF both display a similar high affinity for the CRF1 receptor, the affinity of UCN for the CRF2 receptor is more than 10-fold higher than that of rat/human CRF. UCN mRNA expression is highest in the Edinger-Westphal nucleus and lateral superior olive, with the most prominent terminal fields found in the lateral septum. Because of the higher relative affinity of UCN for the CRF2 receptor and the corresponding neuroanatomical distribution of the highest density of UCN expression and innervation to brain regions preferentially expressing the CRF2 receptor subtype, it has been hypothesized that UCN is the preferred endogenous ligand for the CRF2 receptor. Following central administration, UCN has been demonstrated to produce behavioral and physiological effects that are qualitatively similar to CRF. Quantitatively, however, UCN appears to be a more potent suppressor of ingestive behavior (food and water intake) and a less potent inducer of anxiogenic behavior than CRF. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)85-92
Number of pages8
JournalRegulatory Peptides
Volume93
Issue number1-3
DOIs
StatePublished - Sep 25 2000
Externally publishedYes

Keywords

  • Corticotropin-releasing factor
  • Ingestive behavior
  • Stress
  • Urocortin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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