The neurobiology of neurotensin

focus on neurotensin-dopamine interactions

John Kasckow, Charles Nemeroff

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Neurotensin (NT) is a tridecapeptide which fulfills many of the requisite criteria for a role as a central nervous system (CNS) neurotransmitter. It is closely associated with CNS dopamine neurons and has been shown to interact with dopamine at physiological, anatomical and behavioral levels. Neurotensin is colocalized with dopaminergic neurons in the hypothalamus and midbrain. In addition, it blocks behaviors associated with activation of the dopaminergic pathways. Centrally administered NT has been shown to mimic many of the actions of antipsychotic drugs. In addition, the concentration of NT in cerebrospinal fluid is decreased in patients with schizophrenia. Administration of clinically effective antipsychotic drugs increases concentrations of NT in the caudate nucleus and nucleus accumbens. NT has been shown to play a role in signal transduction by mostly mobilizing calcium stores following inosital phosphate formation. This has been linked to subsequent events in protein phosphorylation. Lipophillic NT receptor agonists may represent a novel approach to the development of a new class of antipsychotic drugs.

Original languageEnglish
Pages (from-to)153-164
Number of pages12
JournalRegulatory Peptides
Volume36
Issue number2
DOIs
StatePublished - Oct 29 1991
Externally publishedYes

Fingerprint

Neurotensin
Neurobiology
Dopamine
Antipsychotic Agents
Dopaminergic Neurons
Neurology
Neurons
Central Nervous System
Neurotensin Receptors
Cerebrospinal fluid
Signal transduction
Phosphorylation
Caudate Nucleus
Nucleus Accumbens
Mesencephalon
Hypothalamus
Neurotransmitter Agents
Cerebrospinal Fluid
Signal Transduction
Schizophrenia

Keywords

  • Behavior
  • Dopamine
  • Neurotensin
  • Pharmacology
  • Schizophrenia
  • Transduction

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

The neurobiology of neurotensin : focus on neurotensin-dopamine interactions. / Kasckow, John; Nemeroff, Charles.

In: Regulatory Peptides, Vol. 36, No. 2, 29.10.1991, p. 153-164.

Research output: Contribution to journalArticle

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