Abstract
Neurotensin (NT) is a tridecapeptide which fulfills many of the requisite criteria for a role as a central nervous system (CNS) neurotransmitter. It is closely associated with CNS dopamine neurons and has been shown to interact with dopamine at physiological, anatomical and behavioral levels. Neurotensin is colocalized with dopaminergic neurons in the hypothalamus and midbrain. In addition, it blocks behaviors associated with activation of the dopaminergic pathways. Centrally administered NT has been shown to mimic many of the actions of antipsychotic drugs. In addition, the concentration of NT in cerebrospinal fluid is decreased in patients with schizophrenia. Administration of clinically effective antipsychotic drugs increases concentrations of NT in the caudate nucleus and nucleus accumbens. NT has been shown to play a role in signal transduction by mostly mobilizing calcium stores following inosital phosphate formation. This has been linked to subsequent events in protein phosphorylation. Lipophillic NT receptor agonists may represent a novel approach to the development of a new class of antipsychotic drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 153-164 |
| Number of pages | 12 |
| Journal | Regulatory Peptides |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 29 1991 |
| Externally published | Yes |
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Keywords
- Behavior
- Dopamine
- Neurotensin
- Pharmacology
- Schizophrenia
- Transduction
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Neuroscience(all)
Cite this
The neurobiology of neurotensin : focus on neurotensin-dopamine interactions. / Kasckow, John; Nemeroff, Charles.
In: Regulatory Peptides, Vol. 36, No. 2, 29.10.1991, p. 153-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The neurobiology of neurotensin
T2 - focus on neurotensin-dopamine interactions
AU - Kasckow, John
AU - Nemeroff, Charles
PY - 1991/10/29
Y1 - 1991/10/29
N2 - Neurotensin (NT) is a tridecapeptide which fulfills many of the requisite criteria for a role as a central nervous system (CNS) neurotransmitter. It is closely associated with CNS dopamine neurons and has been shown to interact with dopamine at physiological, anatomical and behavioral levels. Neurotensin is colocalized with dopaminergic neurons in the hypothalamus and midbrain. In addition, it blocks behaviors associated with activation of the dopaminergic pathways. Centrally administered NT has been shown to mimic many of the actions of antipsychotic drugs. In addition, the concentration of NT in cerebrospinal fluid is decreased in patients with schizophrenia. Administration of clinically effective antipsychotic drugs increases concentrations of NT in the caudate nucleus and nucleus accumbens. NT has been shown to play a role in signal transduction by mostly mobilizing calcium stores following inosital phosphate formation. This has been linked to subsequent events in protein phosphorylation. Lipophillic NT receptor agonists may represent a novel approach to the development of a new class of antipsychotic drugs.
AB - Neurotensin (NT) is a tridecapeptide which fulfills many of the requisite criteria for a role as a central nervous system (CNS) neurotransmitter. It is closely associated with CNS dopamine neurons and has been shown to interact with dopamine at physiological, anatomical and behavioral levels. Neurotensin is colocalized with dopaminergic neurons in the hypothalamus and midbrain. In addition, it blocks behaviors associated with activation of the dopaminergic pathways. Centrally administered NT has been shown to mimic many of the actions of antipsychotic drugs. In addition, the concentration of NT in cerebrospinal fluid is decreased in patients with schizophrenia. Administration of clinically effective antipsychotic drugs increases concentrations of NT in the caudate nucleus and nucleus accumbens. NT has been shown to play a role in signal transduction by mostly mobilizing calcium stores following inosital phosphate formation. This has been linked to subsequent events in protein phosphorylation. Lipophillic NT receptor agonists may represent a novel approach to the development of a new class of antipsychotic drugs.
KW - Behavior
KW - Dopamine
KW - Neurotensin
KW - Pharmacology
KW - Schizophrenia
KW - Transduction
UR - http://www.scopus.com/inward/record.url?scp=0026009378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026009378&partnerID=8YFLogxK
U2 - 10.1016/0167-0115(91)90053-J
DO - 10.1016/0167-0115(91)90053-J
M3 - Article
C2 - 1666685
AN - SCOPUS:0026009378
VL - 36
SP - 153
EP - 164
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 2
ER -