The Neurobiology of Bipolar Disorder

Gregory S. Berns, Charles B. Nemeroff

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The neurobiology of bipolar disorder is reviewed. Bipolar disorder is associated with alterations in central nervous system (CNS) function from the level of large-scale brain circuits to intracellular signal transduction mechanisms. Because of the broad spectrum over which these abnormalities appear, the causative effects are most likely present in the lowest common denominator of all of these systems. Current evidence points to subtle alterations in signal transduction that reverberate downstream both intra- and extracellularly to produce the symptoms of bipolar disorder.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalAmerican Journal of Medical Genetics - Seminars in Medical Genetics
Volume123 C
Issue number1
StatePublished - Nov 15 2003
Externally publishedYes


  • Bipolar disorder
  • Magnetic resonance imaging
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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