The neurobiological basis of mixed depression-anxiety states

L. R. Gulley, C. B. Nemeroff

Research output: Contribution to journalArticle

40 Scopus citations


A recognition of the clinical overlap of symptoms of anxiety disorders and those of affective disorders has brought with it a need to move beyond descriptive definitions of the syndromes to an etiologic and neurobiological understanding of their psychopathology. The authors discuss the neurobiological basis of mixed depression-anxiety states with special attention to the literature on pharmacologic treatment outcome studies, neurotransmitters in anxiety and depression, and the hypothalamic-pituitary- adrenal axis.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalJournal of Clinical Psychiatry
Issue number1 SUPPL.
StatePublished - Jan 1 1993
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health

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