The nature of opiate receptors in toad brain

E. J. Simon, J. M. Hiller, J. Groth, Y. Itzhak, M. J. Holland, S. G. Beck

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

We have previously reported that particulate fractions from the brain of Bufo marinus bind enkephalins and their analogues very poorly, suggesting a low level or virtual absence of δ receptors. A detailed examination has revealed that the predominant opiate receptor subclass in toad brain is of the benzomorphan preferring type. This subclass, though similar to the κ and σ binding sites found in mammalian brain, seems to have a higher affinity for μ-preferring ligands than its mammalian counterpart. Based in our findings, we estimate that toad brain contains 60-70% κ/σ sites, 20-30% μ sites and very few if any δ sites.

Original languageEnglish (US)
Pages (from-to)1367-1370
Number of pages4
JournalLife Sciences
Volume31
Issue number12-13
DOIs
StatePublished - Sep 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Simon, E. J., Hiller, J. M., Groth, J., Itzhak, Y., Holland, M. J., & Beck, S. G. (1982). The nature of opiate receptors in toad brain. Life Sciences, 31(12-13), 1367-1370. https://doi.org/10.1016/0024-3205(82)90383-6