The NAD-glycohydrolase (nga) gene of Streptococcus pyogenes

Dragana Ajdic, William M. McShan, Dragutin J. Savic, Dieter Gerlach, Joseph J. Ferretti

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The gene for NAD-glycohydrolase (nga) of group A streptococci (Streptococcus pyogenes) was identified and shown to be located immediately adjacent to the gene for streptolysin O (slo). The nga gene contains 1341 base pairs and encodes a protein of 447 amino acids, including an N-terminal signal peptide. Results from analysis with the polymerase chain reaction indicated that the nga gene is present in all of the strains tested. Functional extracellular NAD-glycohydrolase, also known as NADase, was detected among a wide variety of clinical isolates and known laboratory strains and shown to be present in 72% of 100 strains examined. In contrast, 92% of strains isolated from patients with invasive streptococcal infections were positive for NADase production. Copyright (C) 2000 Federation of European Microbiological Societies.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalFEMS microbiology letters
Issue number2
StatePublished - Oct 15 2000
Externally publishedYes


  • NAD-glycohydrolase
  • NADase
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology


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