The Na-K-Cl Co-transporter in astrocyte swelling

Arumugam R. Jayakumar, Michael D Norenberg

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Ion channels, exchangers and transporters are known to be involved in cell volume regulation. A disturbance in one or more of these systems may result in loss of ion homeostasis and cell swelling. In particular, activation of the Na+-K+-Cl- cotransporters has been shown to regulate cell volume in many conditions. The Na+-K+-Cl- cotransporters (NKCC) are a class of membrane proteins that transport Na, K, and Cl ions into and out of a wide variety of epithelial and nonepithelial cells. Studies have established the role of NKCC1 in astrocyte swelling/brain edema in ischemia and trauma. Our recent studies suggest that NKCC1 activation is also involved in astrocyte swelling induced by ammonia and in the brain edema in the thioacetamide model of acute liver failure. This review will focus on mechanisms of NKCC1 activation and its contribution to astrocyte swelling/brain edema in neurological disorders, with particular emphasis on ammonia neurotoxicity and acute liver failure.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalMetabolic Brain Disease
Volume25
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Sodium-Potassium-Chloride Symporters
Symporters
Brain Edema
Astrocytes
Swelling
Acute Liver Failure
Cell Size
Ammonia
Brain
Chemical activation
Liver
Ions
Thioacetamide
Membrane Transport Proteins
Nervous System Diseases
Ion Channels
Homeostasis
Ischemia
Epithelial Cells
Wounds and Injuries

Keywords

  • Ammonia
  • Astrocyte swelling
  • Brain edema
  • Hepatic encephalopathy
  • Ischemia
  • Na-K-Cl- cotransporter
  • Trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

The Na-K-Cl Co-transporter in astrocyte swelling. / Jayakumar, Arumugam R.; Norenberg, Michael D.

In: Metabolic Brain Disease, Vol. 25, No. 1, 01.03.2010, p. 31-38.

Research output: Contribution to journalArticle

Jayakumar, Arumugam R. ; Norenberg, Michael D. / The Na-K-Cl Co-transporter in astrocyte swelling. In: Metabolic Brain Disease. 2010 ; Vol. 25, No. 1. pp. 31-38.
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