The morphopathologic substrates of concussion?

J. T. Povlishock, D. P. Becker, J. D. Miller, L. W. Jenkins, W. D. Dietrich

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Abstract

Neuronal inundation with i.v. infused horseradish peroxidase was studied following concussive brain injury by means of both light and electron microscopy. In animals sustaining mechanical brain injury of insufficient intensity as to elicit either microscopic intraparenchymal hemorrhage or other neuropathological change, yet of sufficient intensity as to provoke a physiological concussive response, vascular peroxidase exudation concomitant with neuronal peroxidase inundation occurred throughout the raphe and reticular core. Initially such inundated neurons were totally flooded with the tracer and as such appeared reminiscent of cells visualized in Golgi preparations. However, over the course of a 24-h period these peroxidase flooded neurons apparently organized the peroxidase into vesicles and vacuoles which assumed a perinuclear position from where the peroxidase ultimately reached both the nucleus und nucleolus. It was remarkable that these events occurred without any evidence of subcellular alteration. We interpret such initial inundation with this protein tracer, its ultimate reorganization, and its nuclear and nucleolar uptake as being consistent with some form of subtle and transient neuronal perturbation. We speculate that as such this neuronal perturbation may constitute a morphological correlate of the concussive episode.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalActa neuropathologica
Volume47
Issue number1
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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Keywords

  • Electron microscopy
  • Experimental Concussion
  • Peroxidase, neuronal uptake

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Povlishock, J. T., Becker, D. P., Miller, J. D., Jenkins, L. W., & Dietrich, W. D. (1979). The morphopathologic substrates of concussion? Acta neuropathologica, 47(1), 1-11. https://doi.org/10.1007/BF00698266