The morphologic effects of mitomycin C in mammalian urinary bladder

W. M. Murphy, M. S. Soloway, W. N. Crabtree

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Abstract

This investigation was intended to determine the morphologic changes of mitomycin C. It is part of a series of experiments designed to evaluate the cytologic and histologic effects of topical chemotherapeutic agents using the FANFT experimental model system in mice. The results for mitomycin C are very similar to those previously reported for thio-tepa. They indicate that these chemicals produce few, if any, drug-specific light microscopic alterations. Rather, mitomycin C and thio-tepa apparently act as toxic substances, causing increased exfoliation, degeneration, and necrosis of urothelial cells. The implications of these findings and suggestions for future investigations are discussed.

Original languageEnglish
Pages (from-to)2567-2574
Number of pages8
JournalCancer
Volume47
Issue number11
StatePublished - Jan 1 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Murphy, W. M., Soloway, M. S., & Crabtree, W. N. (1981). The morphologic effects of mitomycin C in mammalian urinary bladder. Cancer, 47(11), 2567-2574.