The morphologic effects of mitomycin C in mammalian urinary bladder

W. M. Murphy, M. S. Soloway, W. N. Crabtree

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This investigation was intended to determine the morphologic changes of mitomycin C. It is part of a series of experiments designed to evaluate the cytologic and histologic effects of topical chemotherapeutic agents using the FANFT experimental model system in mice. The results for mitomycin C are very similar to those previously reported for thio-tepa. They indicate that these chemicals produce few, if any, drug-specific light microscopic alterations. Rather, mitomycin C and thio-tepa apparently act as toxic substances, causing increased exfoliation, degeneration, and necrosis of urothelial cells. The implications of these findings and suggestions for future investigations are discussed.

Original languageEnglish
Pages (from-to)2567-2574
Number of pages8
JournalCancer
Volume47
Issue number11
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Mitomycin
Thiotepa
Urinary Bladder
FANFT
Poisons
Theoretical Models
Necrosis
Light
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Murphy, W. M., Soloway, M. S., & Crabtree, W. N. (1981). The morphologic effects of mitomycin C in mammalian urinary bladder. Cancer, 47(11), 2567-2574.

The morphologic effects of mitomycin C in mammalian urinary bladder. / Murphy, W. M.; Soloway, M. S.; Crabtree, W. N.

In: Cancer, Vol. 47, No. 11, 01.01.1981, p. 2567-2574.

Research output: Contribution to journalArticle

Murphy, WM, Soloway, MS & Crabtree, WN 1981, 'The morphologic effects of mitomycin C in mammalian urinary bladder', Cancer, vol. 47, no. 11, pp. 2567-2574.
Murphy WM, Soloway MS, Crabtree WN. The morphologic effects of mitomycin C in mammalian urinary bladder. Cancer. 1981 Jan 1;47(11):2567-2574.
Murphy, W. M. ; Soloway, M. S. ; Crabtree, W. N. / The morphologic effects of mitomycin C in mammalian urinary bladder. In: Cancer. 1981 ; Vol. 47, No. 11. pp. 2567-2574.
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