The molecular mechanism of lymphocyte-mediated tumor cell lysis

Eckhard R. Podack

Research output: Contribution to journalReview articlepeer-review

153 Scopus citations


Lymphocyte-mediated cytolysis is an important mechanism of immune defense and possibly also of immune surveillance against cancer. Recent major advances in the understanding of its molecular mechanism came from the discovery that lysis was associated with the formation of membrane lesions on target cells caused by cytoplasmic granules from cytolytic lymphocytes. In this review Eckhard Podack summarizes our current knowledge of the molecular events resulting in target cell destruction by cytolytic T-lymphocytes (CTL) and natural killer (NK) cells.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalImmunology Today
Issue number1
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Immunology


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