The molecular basis of chromatin dynamics during nucleotide excision repair

Ling Zhang, Kristi Jones, Feng Gong

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

The assembly of DNA into chromatin in eukaryotic cells affects all DNA-related cellular activities, such as replication, transcription, recombination, and repair. Rearrangement of chromatin structure during nucleotide excision repair (NER) was discovered more than 2 decades ago. However, the molecular basis of chromatin dynamics during NER remains undefined. Pioneering studies in the field of gene transcription have shown that ATP-dependent chromatin-remodeling complexes and histone-modifying enzymes play a critical role in chromatin dynamics during transcription. Similarly, recent studies have demonstrated that the SWI/SNF chromatin-remodeling complex facilitates NER both in vitro and in vivo. Additionally, histone acetylation has also been linked to the NER of ultraviolet light damage. In this article, we will discuss the role of these identified chromatin-modifying activities in NER.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalBiochemistry and Cell Biology
Volume87
Issue number1
DOIs
StatePublished - Feb 1 2009

Keywords

  • Chromatin
  • Histones
  • Nucleotide excision repair
  • SWI/SNF

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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