The mitogen-activated protein kinases, ERK1 and ERK2

Melanie H. Cobb, Jessie E. Hepler, Mangeng Cheng, David Robbins

Research output: Contribution to journalArticle

127 Scopus citations


The MAP kinases are ubiquitous enzymes that are activated in a complex fashion and inactivated by multiple phosphatases including a dedicated dual specificity enzyme. These kinases have a diverse array of substrates with important functions that result in their substantial regulatory impact. The ERK/MAP kinase cascade displays not only downstream but also upstream interactions as well as cross talk with other signaling pathways which fine tunes the cascade in a cell type-specific fashion. Transforming agents utilize this cascade in inducing cell proliferation.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalSeminars in Cancer Biology
Issue number4
StatePublished - Dec 1 1994
Externally publishedYes


  • Extracellular signal-regulated kinase
  • MAP kinase

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Cobb, M. H., Hepler, J. E., Cheng, M., & Robbins, D. (1994). The mitogen-activated protein kinases, ERK1 and ERK2. Seminars in Cancer Biology, 5(4), 261-268.