The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Julia Fritsch; Maria T Abreu

doi:10.1016/j.giec.2019.02.005

The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Julia Fritsch, Maria T Abreu

Medicine

Research output: Contribution to journal › Review article

4 Scopus citations

Abstract

The underlying factors driving the onset and progression of inflammatory bowel disease (IBD) include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD.

Original language	English (US)
Journal	Gastrointestinal Endoscopy Clinics of North America
DOIs	https://doi.org/10.1016/j.giec.2019.02.005
State	Published - Jan 1 2019

Keywords

Bacterial translocation
Colitis
Crohn's disease
Dysbiosis
Host-microbe interactions
Innate immunity
Intestinal inflammation
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.giec.2019.02.005

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Cite this

Fritsch, J., & Abreu, M. T. (2019). The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg? Gastrointestinal Endoscopy Clinics of North America. https://doi.org/10.1016/j.giec.2019.02.005

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abstract = "The underlying factors driving the onset and progression of inflammatory bowel disease (IBD) include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD.",

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