The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Julia Fritsch, Maria T. Abreu

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The underlying factors driving the onset and progression of inflammatory bowel disease (IBD)include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD?

Original languageEnglish (US)
Pages (from-to)381-393
Number of pages13
JournalGastrointestinal Endoscopy Clinics of North America
Volume29
Issue number3
DOIs
StatePublished - Jul 2019

Keywords

  • Bacterial translocation
  • Colitis
  • Crohn's disease
  • Dysbiosis
  • Host-microbe interactions
  • Innate immunity
  • Intestinal inflammation
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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