The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Julia Fritsch; Maria T. Abreu

doi:10.1016/j.giec.2019.02.005

The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Julia Fritsch, Maria T. Abreu

Medicine

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

The underlying factors driving the onset and progression of inflammatory bowel disease (IBD)include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD?

Original language	English (US)
Pages (from-to)	381-393
Number of pages	13
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.giec.2019.02.005
State	Published - Jul 2019

Keywords

Bacterial translocation
Colitis
Crohn's disease
Dysbiosis
Host-microbe interactions
Innate immunity
Intestinal inflammation
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.giec.2019.02.005

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title = "The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?",

abstract = "The underlying factors driving the onset and progression of inflammatory bowel disease (IBD)include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD?",

keywords = "Bacterial translocation, Colitis, Crohn's disease, Dysbiosis, Host-microbe interactions, Innate immunity, Intestinal inflammation, Ulcerative colitis",

author = "Julia Fritsch and Abreu, {Maria T.}",

note = "Funding Information: This work was supported by grants from the National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases R01DK099076, R01DK104844 and T32DK11678; Crohn's and Colitis Foundation Award IBD-0389R; Florida Academic Cancer Center Alliance (FACCA)Award; Pfizer ASPIRE Award; and Takeda Pharmaceuticals Investigator Initiated Research (IIR)Award. Additional funding was provided by The Micky & Madeleine Arison Family Foundation Crohn's & Colitis Discovery Laboratory and Martin Kalser Chair. The authors thank Natasha Kobinger-Wessel for her help preparing the images. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

doi = "10.1016/j.giec.2019.02.005",

language = "English (US)",

volume = "29",

pages = "381--393",

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T2 - What Is the Chicken and What Is the Egg?

AU - Fritsch, Julia

AU - Abreu, Maria T.

N1 - Funding Information: This work was supported by grants from the National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases R01DK099076, R01DK104844 and T32DK11678; Crohn's and Colitis Foundation Award IBD-0389R; Florida Academic Cancer Center Alliance (FACCA)Award; Pfizer ASPIRE Award; and Takeda Pharmaceuticals Investigator Initiated Research (IIR)Award. Additional funding was provided by The Micky & Madeleine Arison Family Foundation Crohn's & Colitis Discovery Laboratory and Martin Kalser Chair. The authors thank Natasha Kobinger-Wessel for her help preparing the images. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/7

Y1 - 2019/7

N2 - The underlying factors driving the onset and progression of inflammatory bowel disease (IBD)include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD?

AB - The underlying factors driving the onset and progression of inflammatory bowel disease (IBD)include the interplay between host genetics, microbiota, and mucosal inflammation. The same environmental triggers that are a risk factor for IBD also alter the microbiota, suggesting a link between the microbiome and IBD. Specific IBD-associated genetic polymorphisms change the microbiome linking host genetics to the microbiota. Microbial changes occur at least simultaneously with new onset IBD, and fecal microbial transplant can ameliorate certain types of IBD. A current debate in the field is which comes first, dysbiosis or inflammation? Can restitution of the microbiome “cure” IBD?

KW - Bacterial translocation

KW - Colitis

KW - Crohn's disease

KW - Dysbiosis

KW - Host-microbe interactions

KW - Innate immunity

KW - Intestinal inflammation

KW - Ulcerative colitis

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DO - 10.1016/j.giec.2019.02.005

M3 - Review article

C2 - 31078242

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VL - 29

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EP - 393

JO - Gastrointestinal Endoscopy Clinics of North America

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SN - 1052-5157

IS - 3

ER -

The Microbiota and the Immune Response: What Is the Chicken and What Is the Egg?

Abstract

Keywords

ASJC Scopus subject areas

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