The Microbiome and Ocular Surface Disease

Research output: Contribution to journalReview article

Abstract

Purpose of Review: The human body lives in a symbiotic relationship with the bacteria, viruses, fungi, and protozoa that make up the microbiome. In this review, we discuss the compositions of the gut and ocular surface microbiomes in relationship to health and disease. Recent Findings: The gut microbiome is dominated by Firmicutes, whereas the ocular surface is dominated by Proteobacteria. The compositions of the microbiome are similar between individuals at the phyla level, but differ at the genus level. Alterations in the microbiome have been associated with disease. For example, ocular diseases such as uveitis, dry eye, and keratitis have been associated with gut dysbiosis. In addition, ocular surface dysbiosis has been reported in diseases including dry eye, blepharitis, keratitis, and diabetic retinopathy. Summary: Compositions of the gut and ocular surface microbiomes have been found to differ in disease states compared with controls. Further understanding of dysbiosis specific to a disease is needed to target these surfaces for therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalCurrent Ophthalmology Reports
Volume7
Issue number3
DOIs
StatePublished - Sep 15 2019

Keywords

  • Dysbiosis
  • Gut microbiome
  • Gut-eye axis
  • Ocular surface disease

ASJC Scopus subject areas

  • Ophthalmology

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