TY - JOUR
T1 - The MHC class I genes of the rhesus monkey
T2 - Different evolutionary histories of MHC class I and II genes in primates
AU - Boyson, Jonathan E.
AU - Shufflebotham, Clare
AU - Cadavid, Luis F.
AU - Urvater, Julie A.
AU - Knapp, Leslie A.
AU - Hughes, Austin L.
AU - Watkins, David I.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996/6/15
Y1 - 1996/6/15
N2 - Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans. To determine the age of the MHC class I C locus and to examine the evolution of the A and B loci we have cloned, sequenced, and in vitro translated 16 MHC class I cDNAs from two unrelated rhesus monkeys (Macaca mulatta) using both cDNA library screening and PCR amplification. Analyses of these sequences suggest that the C locus is not present in the rhesus monkey, indicating that this locus may be of recent origin in gorillas, chimpanzees, and humans. The rhesus monkey's complement of MHC class I genes includes the products of at least one expressed A locus and at least two expressed B loci, indicating that a duplication of the B locus has taken place in the lineage leading to these Old World primates. Comparison of rhesus monkey MHC class I cDNAs to their primate counterparts reveals fundamental differences between MHC class I and class II evolution in primates. Although MHC class II allelic lineages are shared between humans and Old World primates, no such trans- species sharing of allelic lineages is seen at the MHC class I loci.
AB - Homologues of the human HLA-A and -B MHC class I loci have been found in great apes and Old World primates suggesting that these two loci have existed for at least 30 million years. The C locus, however, shows some sequence similarity to the B locus and has been found only in gorillas, chimpanzees, and humans. To determine the age of the MHC class I C locus and to examine the evolution of the A and B loci we have cloned, sequenced, and in vitro translated 16 MHC class I cDNAs from two unrelated rhesus monkeys (Macaca mulatta) using both cDNA library screening and PCR amplification. Analyses of these sequences suggest that the C locus is not present in the rhesus monkey, indicating that this locus may be of recent origin in gorillas, chimpanzees, and humans. The rhesus monkey's complement of MHC class I genes includes the products of at least one expressed A locus and at least two expressed B loci, indicating that a duplication of the B locus has taken place in the lineage leading to these Old World primates. Comparison of rhesus monkey MHC class I cDNAs to their primate counterparts reveals fundamental differences between MHC class I and class II evolution in primates. Although MHC class II allelic lineages are shared between humans and Old World primates, no such trans- species sharing of allelic lineages is seen at the MHC class I loci.
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M3 - Article
C2 - 8648109
AN - SCOPUS:0029886599
VL - 156
SP - 4656
EP - 4665
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 12
ER -