The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma

Kyle Amber, Michael P. McLeod, Keyvan Nouri

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Background The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV. Objective To review the role of MCV in MCC and its potential to influence diagnosis, prognosis, and treatment. Methods and Materials An extensive literature search was performed on MCV and its relationship with other polyomaviruses and MCC. The immune system's role in MCC was also investigated. Results We included 60 articles regarding MCC and MCV and seven pertinent to general processes involved with MCC and MCV. Conclusion Merkel cell polyomavirus appears to affect many aspects of MCC. An understanding of this virus may aid in future therapy options and current pathology protocols in diagnosing MCC. The host's immune function appears to affect MCV's ability to cause cellular transformation leading to MCC.

Original languageEnglish (US)
Pages (from-to)232-238
Number of pages7
JournalDermatologic Surgery
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Fingerprint Dive into the research topics of 'The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma'. Together they form a unique fingerprint.

  • Cite this