TY - JOUR
T1 - The medium chains of the mammalian clathrin‐associated proteins have a homolog in yeast
AU - NAKAYAMA, Yasuhiro
AU - GOEBL, Mark
AU - O'BRINE GRECO, Betsy
AU - LEMMON, Sandy
AU - PINGCHANG CHOW, Elizabeth
AU - KIRCHHAUSEN, Tomas
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/12
Y1 - 1991/12
N2 - We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The predicted protein sequence of AP47 is closely related to rat and calf brain AP50, the corresponding medium chain of the plasma-membrane clathrin-associated protein complex AP-2. We have also identified in the yeast genome an open reading frame encoding a protein of previously unknown function. Referred to here as YAP54, its predicted protein sequence displays a striking homology to AP47. We therefore propose that Yap54 is the medium chain subunit of a putative AP-1 complex in yeast. From the analyses of the optimized sequence alignments of AP47, AP50 and Yap54p, we suggest a model for the domain organization of the medium chains.
AB - We have cloned and sequenced mouse brain AP47, the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The predicted protein sequence of AP47 is closely related to rat and calf brain AP50, the corresponding medium chain of the plasma-membrane clathrin-associated protein complex AP-2. We have also identified in the yeast genome an open reading frame encoding a protein of previously unknown function. Referred to here as YAP54, its predicted protein sequence displays a striking homology to AP47. We therefore propose that Yap54 is the medium chain subunit of a putative AP-1 complex in yeast. From the analyses of the optimized sequence alignments of AP47, AP50 and Yap54p, we suggest a model for the domain organization of the medium chains.
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U2 - 10.1111/j.1432-1033.1991.tb16409.x
DO - 10.1111/j.1432-1033.1991.tb16409.x
M3 - Article
C2 - 1761056
AN - SCOPUS:0026046938
VL - 202
SP - 569
EP - 574
JO - FEBS Journal
JF - FEBS Journal
SN - 1742-464X
IS - 2
ER -