Abstract
Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.
| Original language | English |
|---|---|
| Article number | 61 |
| Journal | MedGenMed Medscape General Medicine |
| Volume | 10 |
| Issue number | 3 |
| State | Published - Apr 24 2008 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
The medical management of primary sclerosing cholangitis. / Michaels, Anthony; Levy, Cynthia.
In: MedGenMed Medscape General Medicine, Vol. 10, No. 3, 61, 24.04.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The medical management of primary sclerosing cholangitis
AU - Michaels, Anthony
AU - Levy, Cynthia
PY - 2008/4/24
Y1 - 2008/4/24
N2 - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.
AB - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.
UR - http://www.scopus.com/inward/record.url?scp=42349093622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42349093622&partnerID=8YFLogxK
M3 - Article
C2 - 18449341
AN - SCOPUS:42349093622
VL - 10
JO - MedGenMed Medscape General Medicine
JF - MedGenMed Medscape General Medicine
SN - 1531-0132
IS - 3
M1 - 61
ER -