The medical management of primary sclerosing cholangitis

Anthony Michaels, Cynthia Levy

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.

Original languageEnglish
Article number61
JournalMedGenMed Medscape General Medicine
Volume10
Issue number3
StatePublished - Apr 24 2008
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Fibrosis
Therapeutics
Cholangiocarcinoma
Liver Transplantation
Uncertainty
Disease Progression
Liver Diseases
Inflammation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The medical management of primary sclerosing cholangitis. / Michaels, Anthony; Levy, Cynthia.

In: MedGenMed Medscape General Medicine, Vol. 10, No. 3, 61, 24.04.2008.

Research output: Contribution to journalArticle

@article{65056619e1244bcdaeb2c50d1eb60475,
title = "The medical management of primary sclerosing cholangitis",
abstract = "Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.",
author = "Anthony Michaels and Cynthia Levy",
year = "2008",
month = "4",
day = "24",
language = "English",
volume = "10",
journal = "MedGenMed Medscape General Medicine",
issn = "1531-0132",
publisher = "Medscape Health Network",
number = "3",

}

TY - JOUR

T1 - The medical management of primary sclerosing cholangitis

AU - Michaels, Anthony

AU - Levy, Cynthia

PY - 2008/4/24

Y1 - 2008/4/24

N2 - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.

AB - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.

UR - http://www.scopus.com/inward/record.url?scp=42349093622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42349093622&partnerID=8YFLogxK

M3 - Article

C2 - 18449341

AN - SCOPUS:42349093622

VL - 10

JO - MedGenMed Medscape General Medicine

JF - MedGenMed Medscape General Medicine

SN - 1531-0132

IS - 3

M1 - 61

ER -