The mechanism whereby growth hormone-release inhibiting hormone (somatostatin) inhibits food stimulated gastric acid secretion in the cat

M. Albinus, E. L. Blair, E. R. Grund, J. D. Reed, D. J. Sanders, A. Gomez-Pan, Andrew V Schally, G. M. Besser

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Growth hormone-release inhibiting hormone (somatostatin) inhibits the gastric acid response to food in concious cats. We have confirmed that this tetradecapeptide blocks the food stimulated gastrin release. However, the inhibition of gastrin release is delayed relative to that of acid secretion, showing that the inhibition of food stimulated acid secretion is by a primary effect on the acid secretory mechanism. No evidence was found of potentiation of either the gastric acid output or serum concentration of gastric in response to food.

Original languageEnglish
Pages (from-to)306-310
Number of pages5
JournalAgents and Actions
Issue number4
StatePublished - Oct 1 1975
Externally publishedYes


ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

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