TY - JOUR
T1 - The measurement of corneal epithelial thickness in response to hypoxia using optical coherence tomography
AU - Wang, Jianhua
AU - Fonn, Desmond
AU - Simpson, Trefford L.
AU - Jones, Lyndon
PY - 2002/3/6
Y1 - 2002/3/6
N2 - PURPOSE: To determine if corneal epithelial thickness increases in association with corneal edema induced by wearing soft contact lenses during eye closure. DESIGN: Experimental study. METHODS: One eye (randomly selected) of twenty noncontact lens wearers (10 males and 10 females, age 35.6 ± 9.6 years) was patched during 3 hours of soft contact lens (SCL) wear and the contralateral eye acted as a control. Corneal and epithelial thickness of both eyes was measured before and after SCL wear using optical coherence tomography (OCT). RESULTS: Immediately after contact lens removal, total corneal thickness was increased significantly by 13.8 ± 2.3% (mean ± SD) compared with baseline (P < .0001, paired t test) and after 100 minutes was still 4.5 ± 2.3% thicker than baseline (P < .0001, paired t test). The control eyes showed no change in total corneal thickness (P > .05, paired t test). Immediately after contact lens removal, corneal epithelial thickness was increased by 1.7 ± 4.8%, but this change was not statistically significant (P > .05, paired t test). Following contact lens removal, epithelial thickness changed significantly (Repeated measure analysis of variance [Re-ANOVA]: F(7,133) = 4.91, pH-F < 0.001) over the next 100 minutes with thinning recorded at 60, 80, and 100 minutes (P < .05, paired t test). There was no significant change over time in epithelial thickness of the control eyes (Re-ANOVA: F(4, 76) = 0.91, pH-F = 0.464). CONCLUSION: OCT demonstrated that corneal epithelial thickness does not increase in response to hypoxia from SCL wear and eye closure, in contrast to a significant increase in total corneal thickness.
AB - PURPOSE: To determine if corneal epithelial thickness increases in association with corneal edema induced by wearing soft contact lenses during eye closure. DESIGN: Experimental study. METHODS: One eye (randomly selected) of twenty noncontact lens wearers (10 males and 10 females, age 35.6 ± 9.6 years) was patched during 3 hours of soft contact lens (SCL) wear and the contralateral eye acted as a control. Corneal and epithelial thickness of both eyes was measured before and after SCL wear using optical coherence tomography (OCT). RESULTS: Immediately after contact lens removal, total corneal thickness was increased significantly by 13.8 ± 2.3% (mean ± SD) compared with baseline (P < .0001, paired t test) and after 100 minutes was still 4.5 ± 2.3% thicker than baseline (P < .0001, paired t test). The control eyes showed no change in total corneal thickness (P > .05, paired t test). Immediately after contact lens removal, corneal epithelial thickness was increased by 1.7 ± 4.8%, but this change was not statistically significant (P > .05, paired t test). Following contact lens removal, epithelial thickness changed significantly (Repeated measure analysis of variance [Re-ANOVA]: F(7,133) = 4.91, pH-F < 0.001) over the next 100 minutes with thinning recorded at 60, 80, and 100 minutes (P < .05, paired t test). There was no significant change over time in epithelial thickness of the control eyes (Re-ANOVA: F(4, 76) = 0.91, pH-F = 0.464). CONCLUSION: OCT demonstrated that corneal epithelial thickness does not increase in response to hypoxia from SCL wear and eye closure, in contrast to a significant increase in total corneal thickness.
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U2 - 10.1016/S0002-9394(01)01382-4
DO - 10.1016/S0002-9394(01)01382-4
M3 - Article
C2 - 11860966
AN - SCOPUS:0036181034
VL - 133
SP - 315
EP - 319
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 3
ER -