The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease

Carmen Rodriguez-Blazquez, Jose Manuel Rojo-Abuin, Mario Alvarez-Sanchez, Tomoko Arakaki, Alberto Bergareche-Yarza, Anabel Chade, Nelida Garretto, Oscar Gershanik, Monica M. Kurtis, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Henry P Moore, Mayela Rodriguez-Violante, Carlos Singer, Barbara C. Tilley, Jing Huang, Glenn T. Stebbins, Christopher G. Goetz, Pablo Martinez-Martin

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25 Scopus citations

Abstract

Objective: To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure. Methods: International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated. Results: MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and-0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p<0.001). Cut-off values for the M-EDL were: 0-2 points, no disability; 3-16, mild; 17-31, moderate; and 32 points or more, severe. Linear regression analysis identified the MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59%). Conclusions: MDS-UPDRS M-EDL proved to be useful for assessing disability in PD.

Original languageEnglish
Pages (from-to)889-893
Number of pages5
JournalParkinsonism and Related Disorders
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2013

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Keywords

  • Assessment
  • Disability
  • MDS-UPDRS
  • Parkinson's disease
  • Rating scales

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology

Cite this

Rodriguez-Blazquez, C., Rojo-Abuin, J. M., Alvarez-Sanchez, M., Arakaki, T., Bergareche-Yarza, A., Chade, A., Garretto, N., Gershanik, O., Kurtis, M. M., Martinez-Castrillo, J. C., Mendoza-Rodriguez, A., Moore, H. P., Rodriguez-Violante, M., Singer, C., Tilley, B. C., Huang, J., Stebbins, G. T., Goetz, C. G., & Martinez-Martin, P. (2013). The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease. Parkinsonism and Related Disorders, 19(10), 889-893. https://doi.org/10.1016/j.parkreldis.2013.05.017