The MAPK cascade is required for mammalian associative learning

Coleen M Atkins, Joel C. Selcher, Joseph J. Petraitis, James M. Trzaskos, J. David Sweatt

Research output: Contribution to journalArticle

887 Citations (Scopus)

Abstract

Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells. Recently MARK activation in post-mitotic cells has been implicated in hippocampal long-term potentiation (LTP), a potential cellular mechanism of learning and memory. Here we investigate the involvement of MAPK in learning and memory in behaving animals. MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning. Two other protein kinases known to be activated during hippocampal LTP, protein kinase C and α-calcium/calmodulin protein kinase II, also were activated in the hippocampus after learning. Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked fear conditioning. Thus, classical conditioning in mammals activates MAPK, which is necessary for consolidation of the resultant learning.

Original languageEnglish
Pages (from-to)602-609
Number of pages8
JournalNature Neuroscience
Volume1
Issue number7
StatePublished - Nov 1 1998
Externally publishedYes

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Mitogen-Activated Protein Kinases
Learning
Long-Term Potentiation
Fear
Hippocampus
MAP Kinase Kinase Kinases
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Classical Conditioning
Mitogen-Activated Protein Kinase Kinases
Protein Kinases
Protein Kinase C
Cell Differentiation
Mammals
Conditioning (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998). The MAPK cascade is required for mammalian associative learning. Nature Neuroscience, 1(7), 602-609.

The MAPK cascade is required for mammalian associative learning. / Atkins, Coleen M; Selcher, Joel C.; Petraitis, Joseph J.; Trzaskos, James M.; Sweatt, J. David.

In: Nature Neuroscience, Vol. 1, No. 7, 01.11.1998, p. 602-609.

Research output: Contribution to journalArticle

Atkins, CM, Selcher, JC, Petraitis, JJ, Trzaskos, JM & Sweatt, JD 1998, 'The MAPK cascade is required for mammalian associative learning', Nature Neuroscience, vol. 1, no. 7, pp. 602-609.
Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD. The MAPK cascade is required for mammalian associative learning. Nature Neuroscience. 1998 Nov 1;1(7):602-609.
Atkins, Coleen M ; Selcher, Joel C. ; Petraitis, Joseph J. ; Trzaskos, James M. ; Sweatt, J. David. / The MAPK cascade is required for mammalian associative learning. In: Nature Neuroscience. 1998 ; Vol. 1, No. 7. pp. 602-609.
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