Abstract
Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells. Recently MARK activation in post-mitotic cells has been implicated in hippocampal long-term potentiation (LTP), a potential cellular mechanism of learning and memory. Here we investigate the involvement of MAPK in learning and memory in behaving animals. MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning. Two other protein kinases known to be activated during hippocampal LTP, protein kinase C and α-calcium/calmodulin protein kinase II, also were activated in the hippocampus after learning. Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked fear conditioning. Thus, classical conditioning in mammals activates MAPK, which is necessary for consolidation of the resultant learning.
| Original language | English |
|---|---|
| Pages (from-to) | 602-609 |
| Number of pages | 8 |
| Journal | Nature Neuroscience |
| Volume | 1 |
| Issue number | 7 |
| State | Published - Nov 1 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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The MAPK cascade is required for mammalian associative learning. / Atkins, Coleen M; Selcher, Joel C.; Petraitis, Joseph J.; Trzaskos, James M.; Sweatt, J. David.
In: Nature Neuroscience, Vol. 1, No. 7, 01.11.1998, p. 602-609.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The MAPK cascade is required for mammalian associative learning
AU - Atkins, Coleen M
AU - Selcher, Joel C.
AU - Petraitis, Joseph J.
AU - Trzaskos, James M.
AU - Sweatt, J. David
PY - 1998/11/1
Y1 - 1998/11/1
N2 - Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells. Recently MARK activation in post-mitotic cells has been implicated in hippocampal long-term potentiation (LTP), a potential cellular mechanism of learning and memory. Here we investigate the involvement of MAPK in learning and memory in behaving animals. MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning. Two other protein kinases known to be activated during hippocampal LTP, protein kinase C and α-calcium/calmodulin protein kinase II, also were activated in the hippocampus after learning. Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked fear conditioning. Thus, classical conditioning in mammals activates MAPK, which is necessary for consolidation of the resultant learning.
AB - Mitogen-activated protein kinase (MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells. Recently MARK activation in post-mitotic cells has been implicated in hippocampal long-term potentiation (LTP), a potential cellular mechanism of learning and memory. Here we investigate the involvement of MAPK in learning and memory in behaving animals. MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning. Two other protein kinases known to be activated during hippocampal LTP, protein kinase C and α-calcium/calmodulin protein kinase II, also were activated in the hippocampus after learning. Inhibition of the specific upstream activator of MAPK, MAPK kinase (MEK), blocked fear conditioning. Thus, classical conditioning in mammals activates MAPK, which is necessary for consolidation of the resultant learning.
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M3 - Article
C2 - 10196568
AN - SCOPUS:0032198366
VL - 1
SP - 602
EP - 609
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 7
ER -