The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins

Ancha Baranova, Dmitry V Ivanov, Nadezda Petrash, Anya Pestova, Mikhail Skoblov, Ilya Kelmanson, Dmitry Shagin, Svetlana Nazarenko, Elena Geraymovych, Oxana Litvin, Anya Tiunova, Timothy L. Born, Natalia Usman, Dmitry Staroverov, Sergey Lukyanov, Yury Panchin

Research output: Contribution to journalArticle

302 Citations (Scopus)

Abstract

We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins. Phylogenetic analysis revealed that pannexins are highly conserved in worms, mollusks, insects and mammals, pointing to their important function. Both innexins and pannexins are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N and C termini. Both the human and mouse genomes contain three pannexin-encoding genes. Mammalian pannexins PANX1 and PANX3 are closely related, with PANX2 more distant. The human and mouse pannexin-1 mRNAs are ubiquitously, although disproportionately, expressed in normal tissues. Human PANX2 is a brain-specific gene; its mouse orthologue, Panx2, is also expressed in certain cell types in developing brain. In silico evaluation of Panx3 expression predicts gene expression in osteoblasts and synovial fibroblasts. The apparent conservation of pannexins between species merits further investigation.

Original languageEnglish
Pages (from-to)706-716
Number of pages11
JournalGenomics
Volume83
Issue number4
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Fingerprint

Connexins
Invertebrates
Genes
Mollusca
Brain
Human Genome
Osteoblasts
Computer Simulation
Insects
Mammals
Fibroblasts
Gene Expression
Messenger RNA
Proteins

Keywords

  • Brain-specific gene
  • Gap junction proteins
  • Innexins
  • Pannexin family
  • PANX1
  • PANX2
  • PANX3
  • Synovial cell-specific gene

ASJC Scopus subject areas

  • Genetics

Cite this

Baranova, A., Ivanov, D. V., Petrash, N., Pestova, A., Skoblov, M., Kelmanson, I., ... Panchin, Y. (2004). The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics, 83(4), 706-716. https://doi.org/10.1016/j.ygeno.2003.09.025

The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. / Baranova, Ancha; Ivanov, Dmitry V; Petrash, Nadezda; Pestova, Anya; Skoblov, Mikhail; Kelmanson, Ilya; Shagin, Dmitry; Nazarenko, Svetlana; Geraymovych, Elena; Litvin, Oxana; Tiunova, Anya; Born, Timothy L.; Usman, Natalia; Staroverov, Dmitry; Lukyanov, Sergey; Panchin, Yury.

In: Genomics, Vol. 83, No. 4, 01.04.2004, p. 706-716.

Research output: Contribution to journalArticle

Baranova, A, Ivanov, DV, Petrash, N, Pestova, A, Skoblov, M, Kelmanson, I, Shagin, D, Nazarenko, S, Geraymovych, E, Litvin, O, Tiunova, A, Born, TL, Usman, N, Staroverov, D, Lukyanov, S & Panchin, Y 2004, 'The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins', Genomics, vol. 83, no. 4, pp. 706-716. https://doi.org/10.1016/j.ygeno.2003.09.025
Baranova, Ancha ; Ivanov, Dmitry V ; Petrash, Nadezda ; Pestova, Anya ; Skoblov, Mikhail ; Kelmanson, Ilya ; Shagin, Dmitry ; Nazarenko, Svetlana ; Geraymovych, Elena ; Litvin, Oxana ; Tiunova, Anya ; Born, Timothy L. ; Usman, Natalia ; Staroverov, Dmitry ; Lukyanov, Sergey ; Panchin, Yury. / The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. In: Genomics. 2004 ; Vol. 83, No. 4. pp. 706-716.
@article{e577e1e3684346ceb8c9cb76def7a108,
title = "The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins",
abstract = "We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins. Phylogenetic analysis revealed that pannexins are highly conserved in worms, mollusks, insects and mammals, pointing to their important function. Both innexins and pannexins are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N and C termini. Both the human and mouse genomes contain three pannexin-encoding genes. Mammalian pannexins PANX1 and PANX3 are closely related, with PANX2 more distant. The human and mouse pannexin-1 mRNAs are ubiquitously, although disproportionately, expressed in normal tissues. Human PANX2 is a brain-specific gene; its mouse orthologue, Panx2, is also expressed in certain cell types in developing brain. In silico evaluation of Panx3 expression predicts gene expression in osteoblasts and synovial fibroblasts. The apparent conservation of pannexins between species merits further investigation.",
keywords = "Brain-specific gene, Gap junction proteins, Innexins, Pannexin family, PANX1, PANX2, PANX3, Synovial cell-specific gene",
author = "Ancha Baranova and Ivanov, {Dmitry V} and Nadezda Petrash and Anya Pestova and Mikhail Skoblov and Ilya Kelmanson and Dmitry Shagin and Svetlana Nazarenko and Elena Geraymovych and Oxana Litvin and Anya Tiunova and Born, {Timothy L.} and Natalia Usman and Dmitry Staroverov and Sergey Lukyanov and Yury Panchin",
year = "2004",
month = "4",
day = "1",
doi = "10.1016/j.ygeno.2003.09.025",
language = "English",
volume = "83",
pages = "706--716",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins

AU - Baranova, Ancha

AU - Ivanov, Dmitry V

AU - Petrash, Nadezda

AU - Pestova, Anya

AU - Skoblov, Mikhail

AU - Kelmanson, Ilya

AU - Shagin, Dmitry

AU - Nazarenko, Svetlana

AU - Geraymovych, Elena

AU - Litvin, Oxana

AU - Tiunova, Anya

AU - Born, Timothy L.

AU - Usman, Natalia

AU - Staroverov, Dmitry

AU - Lukyanov, Sergey

AU - Panchin, Yury

PY - 2004/4/1

Y1 - 2004/4/1

N2 - We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins. Phylogenetic analysis revealed that pannexins are highly conserved in worms, mollusks, insects and mammals, pointing to their important function. Both innexins and pannexins are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N and C termini. Both the human and mouse genomes contain three pannexin-encoding genes. Mammalian pannexins PANX1 and PANX3 are closely related, with PANX2 more distant. The human and mouse pannexin-1 mRNAs are ubiquitously, although disproportionately, expressed in normal tissues. Human PANX2 is a brain-specific gene; its mouse orthologue, Panx2, is also expressed in certain cell types in developing brain. In silico evaluation of Panx3 expression predicts gene expression in osteoblasts and synovial fibroblasts. The apparent conservation of pannexins between species merits further investigation.

AB - We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins. Phylogenetic analysis revealed that pannexins are highly conserved in worms, mollusks, insects and mammals, pointing to their important function. Both innexins and pannexins are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop and intracellular N and C termini. Both the human and mouse genomes contain three pannexin-encoding genes. Mammalian pannexins PANX1 and PANX3 are closely related, with PANX2 more distant. The human and mouse pannexin-1 mRNAs are ubiquitously, although disproportionately, expressed in normal tissues. Human PANX2 is a brain-specific gene; its mouse orthologue, Panx2, is also expressed in certain cell types in developing brain. In silico evaluation of Panx3 expression predicts gene expression in osteoblasts and synovial fibroblasts. The apparent conservation of pannexins between species merits further investigation.

KW - Brain-specific gene

KW - Gap junction proteins

KW - Innexins

KW - Pannexin family

KW - PANX1

KW - PANX2

KW - PANX3

KW - Synovial cell-specific gene

UR - http://www.scopus.com/inward/record.url?scp=12144288999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144288999&partnerID=8YFLogxK

U2 - 10.1016/j.ygeno.2003.09.025

DO - 10.1016/j.ygeno.2003.09.025

M3 - Article

VL - 83

SP - 706

EP - 716

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 4

ER -