The mAKAP signalosome and cardiac myocyte hypertrophy

Andrea L. Bauman, Jennifer J.Carlisle Michel, Edward Henson, Kimberly L. Dodge-Kafka, Michael S. Kapiloff

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Cardiac hypertrophy is regulated by a large intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cell growth. In the last few years, it has become apparent that multimolecular signaling complexes or 'signalosomes' are important for mediating crosstalk between different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to upstream cAMP, Ca2+, and mitogen-activated protein kinase signaling. The mAKAPβ signalosome is important for the control of NFATc transcription factor activity and for the overall induction of myocyte hypertrophy.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalIUBMB life
Volume59
Issue number3
DOIs
StatePublished - 2007

Keywords

  • Calcineurin
  • Epac1
  • ERK5
  • Heart
  • Hypertrophy
  • mAKAP
  • NFATc
  • PDE4D3
  • PKA
  • Ryanodine receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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