The mAKAP signaling complex: Integration of cAMP, calcium, and MAP kinase signaling pathways

Kimberly L. Dodge-Kafka, Michael S. Kapiloff

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Following its production by adenylyl cyclases, the second messenger cAMP is in involved in pleiotrophic signal transduction. The effectors of cAMP include the cAMP-dependent protein kinase (PKA), the guanine nucleotide exchange factor Epac (exchange protein activated by cAMP), and cAMP-dependent ion channels. In turn, cAMP signaling is attenuated by phosphodiesterase-catalyzed degradation. The association of cAMP effectors and the enzymes that regulate cAMP concentration into signaling complexes helps to explain the differential signaling initiated by members of the Gs-protein coupled receptor family. The signal transduction complex formed by the scaffold protein mAKAP (muscle A kinase-anchoring protein) at the nuclear envelope of both striated myocytes and neurons contains three cAMP-binding proteins, PKA, Epac1, and the phosphodiesterase PDE4D3. In addition, the mAKAP complex also contains components of the ERK5 MAP kinase signaling pathway, the calcium release channel ryanodine receptor and the phosphatases PP2A as well as calcineurin. Analysis of the mAKAP complex illustrates how a macromolecular complex can serve as a node in the intracellular signaling network of cardiac myocytes to integrate multiple cAMP signals with those of calcium and MAP kinases to regulate the hypertrophic actions of several hormones.

Original languageEnglish (US)
Pages (from-to)593-602
Number of pages10
JournalEuropean Journal of Cell Biology
Volume85
Issue number7
DOIs
StatePublished - Jul 5 2006

Keywords

  • Calcineurin
  • cAMP signaling
  • Cardiac myocytes
  • ERK5
  • mAKAP
  • Nesprin
  • NFAT
  • PDE4D3
  • PKA

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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