The main function of IL-2 is to promote the development of T regulatory cells

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmunity through the production of CD4+CD25+ T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells.

Original languageEnglish
Pages (from-to)961-965
Number of pages5
JournalJournal of Leukocyte Biology
Volume74
Issue number6
DOIs
StatePublished - Dec 1 2003

Fingerprint

Regulatory T-Lymphocytes
Interleukin-2
Autoimmunity
T-Lymphocytes
Intercellular Signaling Peptides and Proteins
Self Tolerance
Antigens
Interleukin-2 Receptors
Thymus Gland
Apoptosis

Keywords

  • Autoimmunity
  • CD4CD25
  • IL-2

ASJC Scopus subject areas

  • Cell Biology

Cite this

The main function of IL-2 is to promote the development of T regulatory cells. / Malek, Thomas.

In: Journal of Leukocyte Biology, Vol. 74, No. 6, 01.12.2003, p. 961-965.

Research output: Contribution to journalArticle

@article{6b230562793d4ed38772ebb37295f8f1,
title = "The main function of IL-2 is to promote the development of T regulatory cells",
abstract = "Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmunity through the production of CD4+CD25+ T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells.",
keywords = "Autoimmunity, CD4CD25, IL-2",
author = "Thomas Malek",
year = "2003",
month = "12",
day = "1",
doi = "10.1189/jlb.0603272",
language = "English",
volume = "74",
pages = "961--965",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "6",

}

TY - JOUR

T1 - The main function of IL-2 is to promote the development of T regulatory cells

AU - Malek, Thomas

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmunity through the production of CD4+CD25+ T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells.

AB - Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmunity through the production of CD4+CD25+ T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells.

KW - Autoimmunity

KW - CD4CD25

KW - IL-2

UR - http://www.scopus.com/inward/record.url?scp=0348047537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0348047537&partnerID=8YFLogxK

U2 - 10.1189/jlb.0603272

DO - 10.1189/jlb.0603272

M3 - Article

C2 - 12960253

AN - SCOPUS:0348047537

VL - 74

SP - 961

EP - 965

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 6

ER -