The local paracrine actions of the pancreatic α-cell

Rayner Rodriguez-Diaz, Alejandro Tamayo, Manami Hara, Alejandro Caicedo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Secretion of glucagon from the pancreatic α-cells is conventionally seen as the first and most important defense against hypoglycemia. Recent findings, however, show that α-cell signals stimulate insulin secretion from the neighboring β-cell. This article focuses on these seemingly counterintuitive local actions of α-cells and describes how they impact islet biology and glucose metabolism. It is mostly based on studies published in the last decade on the physiology of α-cells in human islets and incorporates results from rodents where appropriate. As this and the accompanying articles show, the emerging picture of α-cell function is one of increased complexity that needs to be considered when developing new therapies aimed at promoting islet function in the context of diabetes.

Original languageEnglish (US)
Pages (from-to)550-558
Number of pages9
Issue number4
StatePublished - Apr 1 2020

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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