The ligand/RAGE axis: Lighting the fuse and igniting vascular stress

Shi Fang Yan, Yoshifumi Naka, Barry I. Hudson, Kevan Herold, Shi Du Yan, Ravichandran Ramasamy, Ann Marie Schmidt

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Vascular inflammation contributes critically to the initiation and progression of atherosclerosis. These processes are accelerated in hyperglycemia and play key roles in the increased incidence and severity of myocardial infarction and stroke observed in diabetes. Evidence suggests that the ligands of the receptor for advanced glycation endproducts (RAGE), a multiligand member of the immunoglobulin superfamily, interact with this receptor to play important roles in both early development and progression of atherosclerosis and vascular inflammation. Studies in animal models of vascular injury underscored the potent impact of RAGE blockade; administration of ligand-binding decoys of RAGE or antibodies to the receptor reduced the consequences of diabetes, hyperlipidemia, and physical injury to the vessel wall. This review focuses on the ligand repertoire of RAGE, the impact of ligand-RAGE interaction, and the potent effect of RAGE blockade in rodent models of vascular injury.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalCurrent atherosclerosis reports
Issue number3
StatePublished - May 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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