The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases

Takuya Fukushima, Yasushi Miyazaki, Hideki Tsushima, Chizuko Tsutsumi, Jun Taguchi, Shinichiro Yoshida, Kazutaka Kuriyama, David Scadden, Stephen Nimer, Masao Tomonaga

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

ETS proteins (such as PU.1, Fli-1 and ETS-1) have been shown to play important roles in normal and abnormal hematopoiesis. We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis. ELF-1 and MEF were expressed in all samples, whereas NERF was not. The relative expression (RE) of MEF, but not ELF-1, was significantly lower (P<0.0001) in AML with t(8;21) and t(15;17) compared with AML with normal karyotype. The pattern of MEF expression was not uniform among cells with CD34(+)/CD33(+). It is suggested that the low RE of MEF might be part of a gene expression profile characterizing AML with a good prognosis.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalLeukemia Research
Volume27
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

Keywords

  • AML
  • ETS genes
  • Gene expression
  • MEF
  • Transcription factor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Fukushima, T., Miyazaki, Y., Tsushima, H., Tsutsumi, C., Taguchi, J., Yoshida, S., Kuriyama, K., Scadden, D., Nimer, S., & Tomonaga, M. (2003). The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. Leukemia Research, 27(5), 387-392. https://doi.org/10.1016/S0145-2126(02)00214-X