The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases

Takuya Fukushima, Yasushi Miyazaki, Hideki Tsushima, Chizuko Tsutsumi, Jun Taguchi, Shinichiro Yoshida, Kazutaka Kuriyama, David Scadden, Stephen D Nimer, Masao Tomonaga

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

ETS proteins (such as PU.1, Fli-1 and ETS-1) have been shown to play important roles in normal and abnormal hematopoiesis. We examined the expression of the ELF subfamily of ETS genes (ELF-1, MEF and NERF) in acute myeloid leukemia (AML) cells using Northern blot analysis. ELF-1 and MEF were expressed in all samples, whereas NERF was not. The relative expression (RE) of MEF, but not ELF-1, was significantly lower (P<0.0001) in AML with t(8;21) and t(15;17) compared with AML with normal karyotype. The pattern of MEF expression was not uniform among cells with CD34(+)/CD33(+). It is suggested that the low RE of MEF might be part of a gene expression profile characterizing AML with a good prognosis.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalLeukemia Research
Volume27
Issue number5
DOIs
StatePublished - May 1 2003
Externally publishedYes

Fingerprint

Acute Myeloid Leukemia
Hematopoiesis
Myeloid Cells
Karyotype
Transcriptome
Northern Blotting
Genes
Proteins

Keywords

  • AML
  • ETS genes
  • Gene expression
  • MEF
  • Transcription factor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Fukushima, T., Miyazaki, Y., Tsushima, H., Tsutsumi, C., Taguchi, J., Yoshida, S., ... Tomonaga, M. (2003). The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. Leukemia Research, 27(5), 387-392. https://doi.org/10.1016/S0145-2126(02)00214-X

The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. / Fukushima, Takuya; Miyazaki, Yasushi; Tsushima, Hideki; Tsutsumi, Chizuko; Taguchi, Jun; Yoshida, Shinichiro; Kuriyama, Kazutaka; Scadden, David; Nimer, Stephen D; Tomonaga, Masao.

In: Leukemia Research, Vol. 27, No. 5, 01.05.2003, p. 387-392.

Research output: Contribution to journalArticle

Fukushima, T, Miyazaki, Y, Tsushima, H, Tsutsumi, C, Taguchi, J, Yoshida, S, Kuriyama, K, Scadden, D, Nimer, SD & Tomonaga, M 2003, 'The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases', Leukemia Research, vol. 27, no. 5, pp. 387-392. https://doi.org/10.1016/S0145-2126(02)00214-X
Fukushima, Takuya ; Miyazaki, Yasushi ; Tsushima, Hideki ; Tsutsumi, Chizuko ; Taguchi, Jun ; Yoshida, Shinichiro ; Kuriyama, Kazutaka ; Scadden, David ; Nimer, Stephen D ; Tomonaga, Masao. / The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases. In: Leukemia Research. 2003 ; Vol. 27, No. 5. pp. 387-392.
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