The Landscape of long noncoding RNA classification

Georges St.Laurent, Claes R Wahlestedt, Philipp Kapranov

Research output: Contribution to journalArticle

322 Citations (Scopus)

Abstract

Advances in the depth and quality of transcriptome sequencing have revealed many new classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to accommodate these new findings, even though the real dimensions and complexity of the noncoding transcriptome remain unknown. Although evidence of functionality of specific lncRNAs continues to accumulate, conflicting, confusing, and overlapping terminology has fostered ambiguity and lack of clarity in the field in general. The lack of fundamental conceptual unambiguous classification framework results in a number of challenges in the annotation and interpretation of noncoding transcriptome data. It also might undermine integration of the new genomic methods and datasets in an effort to unravel the function of lncRNA. Here, we review existing lncRNA classifications, nomenclature, and terminology. Then, we describe the conceptual guidelines that have emerged for their classification and functional annotation based on expanding and more comprehensive use of large systems biology-based datasets.

Original languageEnglish (US)
Pages (from-to)249-251
Number of pages3
JournalTrends in Genetics
Volume31
Issue number5
DOIs
StatePublished - May 1 2015

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Long Noncoding RNA
Transcriptome
Terminology
Systems Biology
Guidelines

Keywords

  • Annotation of long non-coding RNAs
  • Classification of long non-coding RNAs
  • Function of long non-coding RNAs
  • LincRNA
  • LncRNA
  • Long non-coding RNA
  • Systems biology
  • Transcriptome
  • VlincRNA

ASJC Scopus subject areas

  • Genetics

Cite this

The Landscape of long noncoding RNA classification. / St.Laurent, Georges; Wahlestedt, Claes R; Kapranov, Philipp.

In: Trends in Genetics, Vol. 31, No. 5, 01.05.2015, p. 249-251.

Research output: Contribution to journalArticle

St.Laurent, Georges ; Wahlestedt, Claes R ; Kapranov, Philipp. / The Landscape of long noncoding RNA classification. In: Trends in Genetics. 2015 ; Vol. 31, No. 5. pp. 249-251.
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