The itchy scalp - scratching for an explanation

Ghada A. Bin Saif, Marna E. Ericson, Gil Yosipovitch

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Scalp pruritus is a common complaint that is considered a diagnostically and therapeutically challenging situation. Scalp skin has a unique neural structure that contains densely innervated hair follicles and dermal vasculature. In spite of the recent advances in our understanding of itch pathophysiology, scalp itching has not been studied as yet. In this review, we summarize the current knowledge on the neurobiology of scalp and hair follicles as well as itch mediators and provide a putative mechanism for scalp itch with special emphasis on neuroanatomy and pathophysiology.

Original languageEnglish (US)
Pages (from-to)959-968
Number of pages10
JournalExperimental dermatology
Issue number12
StatePublished - Dec 2011
Externally publishedYes


  • Hair follicle
  • Innervation
  • Pruritus
  • Scalp

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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