The Italian version of the “frailty index” based on deficits in health

a validation study

Pasquale Abete, Claudia Basile, Giulia Bulli, Francesco Curcio, Ilaria Liguori, David Della Morte, Gaetano Gargiulo, Assunta Langellotto, Gianluca Testa, Gianluigi Galizia, Domenico Bonaduce, Francesco Cacciatore

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aim: Several measurements were taken for frailty classification in geriatric population. “Frailty index” is based on “deficits in health,” but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of “frailty index” for the Italian geriatric community. Methods: The validation of Italian frailty index (IFi) is based on a cohort study that enrolled 1077 non-disabled outpatients aged 65 years or older (81.3 ± 6.5 years) in Naples (Italy). IFi has been expressed as a ratio of deficits present/deficits considered after a comprehensive geriatric assessment. IFi was stratified in light, moderate and severe frailty. Mortality, disability (considering an increase in ADL lost ≥1 from the baseline) and hospitalization were considered at 3, 6, 12, 18 and 24 months of follow-up. Area under curve (AUC) was evaluated for both Fried’s and IFi frailty index. Result: At the end of follow-up, mortality increased from 1.0 to 30.3%, disability from 40.9 to 92.3% and hospitalization from 0.0 to 59.0% (p < 0.001 for trend). Multivariate analysis shows that the relative risk for unit increase in IFi is 1.09 (95% CI = 1.01–1.17, p = 0.013) for mortality, 1.04 (95% CI = 1.01–1.06, p = 0.024) for disability and 1.03 (95% CI = 1.01–1.07, p = 0.041) for hospitalization. AUC is higher in IFi with respect to Fried’s frailty index when considering mortality (0.809 vs. 0.658, respectively), disability (0.800 vs. 0.729, respectively) and hospitalization (0.707 vs. 0.646, respectively). Conclusions: IFi is a valid measure of frailty after the comprehensive geriatric assessment in an Italian cohort of non-institutionalized patients.

Original languageEnglish (US)
Pages (from-to)913-926
Number of pages14
JournalAging clinical and experimental research
Volume29
Issue number5
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Fingerprint

Validation Studies
Hospitalization
Geriatric Assessment
Mortality
Health
Geriatrics
Area Under Curve
Activities of Daily Living
Italy
Cohort Studies
Outpatients
Multivariate Analysis
Light
Population

Keywords

  • Deficits in health
  • Frailty
  • Frailty index

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

The Italian version of the “frailty index” based on deficits in health : a validation study. / Abete, Pasquale; Basile, Claudia; Bulli, Giulia; Curcio, Francesco; Liguori, Ilaria; Della Morte, David; Gargiulo, Gaetano; Langellotto, Assunta; Testa, Gianluca; Galizia, Gianluigi; Bonaduce, Domenico; Cacciatore, Francesco.

In: Aging clinical and experimental research, Vol. 29, No. 5, 01.10.2017, p. 913-926.

Research output: Contribution to journalArticle

Abete, P, Basile, C, Bulli, G, Curcio, F, Liguori, I, Della Morte, D, Gargiulo, G, Langellotto, A, Testa, G, Galizia, G, Bonaduce, D & Cacciatore, F 2017, 'The Italian version of the “frailty index” based on deficits in health: a validation study', Aging clinical and experimental research, vol. 29, no. 5, pp. 913-926. https://doi.org/10.1007/s40520-017-0793-9
Abete, Pasquale ; Basile, Claudia ; Bulli, Giulia ; Curcio, Francesco ; Liguori, Ilaria ; Della Morte, David ; Gargiulo, Gaetano ; Langellotto, Assunta ; Testa, Gianluca ; Galizia, Gianluigi ; Bonaduce, Domenico ; Cacciatore, Francesco. / The Italian version of the “frailty index” based on deficits in health : a validation study. In: Aging clinical and experimental research. 2017 ; Vol. 29, No. 5. pp. 913-926.
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abstract = "Background and Aim: Several measurements were taken for frailty classification in geriatric population. “Frailty index” is based on “deficits in health,” but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of “frailty index” for the Italian geriatric community. Methods: The validation of Italian frailty index (IFi) is based on a cohort study that enrolled 1077 non-disabled outpatients aged 65 years or older (81.3 ± 6.5 years) in Naples (Italy). IFi has been expressed as a ratio of deficits present/deficits considered after a comprehensive geriatric assessment. IFi was stratified in light, moderate and severe frailty. Mortality, disability (considering an increase in ADL lost ≥1 from the baseline) and hospitalization were considered at 3, 6, 12, 18 and 24 months of follow-up. Area under curve (AUC) was evaluated for both Fried’s and IFi frailty index. Result: At the end of follow-up, mortality increased from 1.0 to 30.3{\%}, disability from 40.9 to 92.3{\%} and hospitalization from 0.0 to 59.0{\%} (p < 0.001 for trend). Multivariate analysis shows that the relative risk for unit increase in IFi is 1.09 (95{\%} CI = 1.01–1.17, p = 0.013) for mortality, 1.04 (95{\%} CI = 1.01–1.06, p = 0.024) for disability and 1.03 (95{\%} CI = 1.01–1.07, p = 0.041) for hospitalization. AUC is higher in IFi with respect to Fried’s frailty index when considering mortality (0.809 vs. 0.658, respectively), disability (0.800 vs. 0.729, respectively) and hospitalization (0.707 vs. 0.646, respectively). Conclusions: IFi is a valid measure of frailty after the comprehensive geriatric assessment in an Italian cohort of non-institutionalized patients.",
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AU - Basile, Claudia

AU - Bulli, Giulia

AU - Curcio, Francesco

AU - Liguori, Ilaria

AU - Della Morte, David

AU - Gargiulo, Gaetano

AU - Langellotto, Assunta

AU - Testa, Gianluca

AU - Galizia, Gianluigi

AU - Bonaduce, Domenico

AU - Cacciatore, Francesco

PY - 2017/10/1

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N2 - Background and Aim: Several measurements were taken for frailty classification in geriatric population. “Frailty index” is based on “deficits in health,” but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of “frailty index” for the Italian geriatric community. Methods: The validation of Italian frailty index (IFi) is based on a cohort study that enrolled 1077 non-disabled outpatients aged 65 years or older (81.3 ± 6.5 years) in Naples (Italy). IFi has been expressed as a ratio of deficits present/deficits considered after a comprehensive geriatric assessment. IFi was stratified in light, moderate and severe frailty. Mortality, disability (considering an increase in ADL lost ≥1 from the baseline) and hospitalization were considered at 3, 6, 12, 18 and 24 months of follow-up. Area under curve (AUC) was evaluated for both Fried’s and IFi frailty index. Result: At the end of follow-up, mortality increased from 1.0 to 30.3%, disability from 40.9 to 92.3% and hospitalization from 0.0 to 59.0% (p < 0.001 for trend). Multivariate analysis shows that the relative risk for unit increase in IFi is 1.09 (95% CI = 1.01–1.17, p = 0.013) for mortality, 1.04 (95% CI = 1.01–1.06, p = 0.024) for disability and 1.03 (95% CI = 1.01–1.07, p = 0.041) for hospitalization. AUC is higher in IFi with respect to Fried’s frailty index when considering mortality (0.809 vs. 0.658, respectively), disability (0.800 vs. 0.729, respectively) and hospitalization (0.707 vs. 0.646, respectively). Conclusions: IFi is a valid measure of frailty after the comprehensive geriatric assessment in an Italian cohort of non-institutionalized patients.

AB - Background and Aim: Several measurements were taken for frailty classification in geriatric population. “Frailty index” is based on “deficits in health,” but it is still not available in Italian version. Thus, the aim of the present work was to validate a version of “frailty index” for the Italian geriatric community. Methods: The validation of Italian frailty index (IFi) is based on a cohort study that enrolled 1077 non-disabled outpatients aged 65 years or older (81.3 ± 6.5 years) in Naples (Italy). IFi has been expressed as a ratio of deficits present/deficits considered after a comprehensive geriatric assessment. IFi was stratified in light, moderate and severe frailty. Mortality, disability (considering an increase in ADL lost ≥1 from the baseline) and hospitalization were considered at 3, 6, 12, 18 and 24 months of follow-up. Area under curve (AUC) was evaluated for both Fried’s and IFi frailty index. Result: At the end of follow-up, mortality increased from 1.0 to 30.3%, disability from 40.9 to 92.3% and hospitalization from 0.0 to 59.0% (p < 0.001 for trend). Multivariate analysis shows that the relative risk for unit increase in IFi is 1.09 (95% CI = 1.01–1.17, p = 0.013) for mortality, 1.04 (95% CI = 1.01–1.06, p = 0.024) for disability and 1.03 (95% CI = 1.01–1.07, p = 0.041) for hospitalization. AUC is higher in IFi with respect to Fried’s frailty index when considering mortality (0.809 vs. 0.658, respectively), disability (0.800 vs. 0.729, respectively) and hospitalization (0.707 vs. 0.646, respectively). Conclusions: IFi is a valid measure of frailty after the comprehensive geriatric assessment in an Italian cohort of non-institutionalized patients.

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