The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia

the MacTel Study Group

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Purpose. To document the progression of a break in the photoreceptor inner segment/outer segment (IS/OS) junction layer and its functional correlates over time in the natural history of type 2 idiopathic macular telangiectasia (type 2 MacTel). Methods. Patients with at least 1 year of follow-up were selected from the MacTel Study. En face images were created by manual segmentation of the IS/OS junctional line in volume scans acquired using a spatial-domain optical coherence tomography retinal imaging unit. Retinal sensitivity thresholds were determined using a retinal microperimeter unit. Aggregate retinal sensitivity loss within IS/OS lesions was calculated. Changes over time in an area of IS/OS defects and retinal sensitivity were analyzed. Results. Thirty-nine eyes of 23 patients (mean age: 62.3 ± 9.2 years) were analyzed. Mean follow-up time was 1.9 years (range: 1-3 years). Mean IS/OS break area at baseline was 0.575 mm2 (SE = 0.092, 95% confidence interval [CI]: 0.394-0.756 mm2). The cluster-adjusted mean annual progression rate in IS/OS break area was 0.140 mm2 (SE = 0.040, 95% CI: 0.062- 0.218 mm2, P < 0.001). Mean aggregate retinal sensitivity loss was at baseline 28.56 dB (SE1/45.43, 95% CI: 17.32-39.80 dB, n = 28), a positive correlation with IS/OS lesion area was present (P < 0.001). The mean annual rate of change in aggregate sensitivity loss was 5.14 dB (SE1/41.51, 95% CI: 2.19-8.10 dB, P < 0.001, n = 37), a significant correlation with lesion area increase was found (P = 0.006). Conclusions. Both IS/OS break area and rate of enlargement correlate with aggregate retinal sensitivity loss in type 2 MacTel. En face OCT imaging of the IS/OS layer provides a functionally relevant method for documenting disease progression in type 2 MacTel.

Original languageEnglish (US)
Pages (from-to)7889-7895
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number12
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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