The ischemic exercise test in normal adults and in patients with weakness and cramps

Rosalind A. Coleman, Jeffrey M. Stajich, Virginia W. Pact, Margaret A. Pericak‐Vance

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Data from 23 normal men and women were used to derive 95% confidence limits for maximum changes in ammonia and lactate values following ischemic forearm exercise. Most normal subjects raised serum lactate and ammonia concentrations more than 20 mg/dl and 100 μg/dl, respectively, over baseline values. No significant correlations were found among age, sex, duration of exercise, or estimate of work performed and the maximum ammonia and lactate values achieved. When 70 patients with complaints of weakness, fatigue, or cramps were evaluated, the ischemic exercise test identified 5 patients who proved to have defects in glycolysis or purine metabolism. The test also distinguished those patients with type III glycogen storage disease who lacked debrancher enzyme activity in muscle.

Original languageEnglish (US)
Pages (from-to)216-221
Number of pages6
JournalMuscle & Nerve
Issue number3
StatePublished - Mar 1986
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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