The investigation onresorcinarenes towards either inhibiting or promoting insulin fibrillation

Xu Han, Chuan Tian, Ingrid Gandra, Valeria Eslava, Diana Galindres, Edgar Vargas, Roger Leblanc

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Different tail-engineered resorcinarenes have been examined for insulin fibrillation by experimental and computational studies. The resorcinarene showed aprom-ising effect on the inhibition of insulin fibrillation, studied using a ThT assay, circular dichroism spectroscopy, and atomic force microscopy. Both the ThT assay and computational results indicate the tail from the resorcinarene has an impact on insulin fibrillation by either inhibition or promotion because of the resident position on insulin. These observations have significant biological implications in the design of drug molecules as well asthe development of potential therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)17903-17907
Number of pages5
JournalChemistry - A European Journal
Volume23
Issue number71
DOIs
StatePublished - 2017

Keywords

  • Biological chemistry
  • Fibrillation
  • Insulin macrocycles
  • Resorcinarene

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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