The Investigation on Resorcinarenes towards either Inhibiting or Promoting Insulin Fibrillation

Xu Han, Chuan Tian, Ingrid Gandra, Valeria Eslava, Diana Galindres, Edgar Vargas, Roger Leblanc

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Different tail-engineered resorcinarenes have been examined for insulin fibrillation by experimental and computational studies. The resorcinarene showed a promising effect on the inhibition of insulin fibrillation, studied using a ThT assay, circular dichroism spectroscopy, and atomic force microscopy. Both the ThT assay and computational results indicate the tail from the resorcinarene has an impact on insulin fibrillation by either inhibition or promotion because of the resident position on insulin. These observations have significant biological implications in the design of drug molecules as well as the development of potential therapeutic strategies.

Original languageEnglish (US)
JournalChemistry - A European Journal
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Insulin
Assays
Circular dichroism spectroscopy
Atomic force microscopy
Molecules
Pharmaceutical Preparations
resorcinarene

Keywords

  • Biological chemistry
  • Fibrillation
  • Insulin
  • Macrocycles
  • Resorcinarene

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

The Investigation on Resorcinarenes towards either Inhibiting or Promoting Insulin Fibrillation. / Han, Xu; Tian, Chuan; Gandra, Ingrid; Eslava, Valeria; Galindres, Diana; Vargas, Edgar; Leblanc, Roger.

In: Chemistry - A European Journal, 01.01.2017.

Research output: Contribution to journalArticle

Han, Xu ; Tian, Chuan ; Gandra, Ingrid ; Eslava, Valeria ; Galindres, Diana ; Vargas, Edgar ; Leblanc, Roger. / The Investigation on Resorcinarenes towards either Inhibiting or Promoting Insulin Fibrillation. In: Chemistry - A European Journal. 2017.
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