The interpeduncular nucleus regulates nicotine's effects on free-field activity

Ian Hentall, L. Gollapudi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Partial lesions were made with kainic acid in the interpeduncular nucleus of the ventral midbrain of the rat. Compared with sham-operated controls, lesions significantly (p < 0.25) blunted the early (< 60 min) free-field locomotor hypoactivity caused by nicotine (0.5 mg kg-1, i.m.), enhanced the later (60-120 min) nicotine-induced hyperactivity, and raised spontaneous nocturnal activity. Lesions reduced the extent of immunohistological staining for choline acetyltransferase in the interpeduncular nucleus (p < 0.025), but not for tyrosine hydroxylase in the surrounding catecholaminergic A10 region.. We conclude that the interpeduncular nicotinic depression of locomotor nicotinic arousal mechanisms located elsewhere in the brain.

Original languageEnglish
Pages (from-to)2469-2472
Number of pages4
JournalNeuroReport
Volume6
Issue number18
StatePublished - Dec 1 1995
Externally publishedYes

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Nicotine
Choline O-Acetyltransferase
Kainic Acid
antineoplaston A10
Tyrosine 3-Monooxygenase
Mesencephalon
Arousal
Staining and Labeling
Brain
Interpeduncular Nucleus

Keywords

  • Acetylcholine
  • Arousal
  • Kainic acid
  • Mecamylamine
  • Midbrain
  • Nicotine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The interpeduncular nucleus regulates nicotine's effects on free-field activity. / Hentall, Ian; Gollapudi, L.

In: NeuroReport, Vol. 6, No. 18, 01.12.1995, p. 2469-2472.

Research output: Contribution to journalArticle

Hentall, I & Gollapudi, L 1995, 'The interpeduncular nucleus regulates nicotine's effects on free-field activity', NeuroReport, vol. 6, no. 18, pp. 2469-2472.
Hentall, Ian ; Gollapudi, L. / The interpeduncular nucleus regulates nicotine's effects on free-field activity. In: NeuroReport. 1995 ; Vol. 6, No. 18. pp. 2469-2472.
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