The interpeduncular nucleus regulates nicotine’s effects on free-field activity

Ian D. Hentall, Lakshmi Gollapudi

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Partial lesions were made with kainic acid in the interpeduncular nucleus of the ventral midbrain of the rat. Compared with sham-operated controls, lesions significantly (p < 0.25) blunted the early (< 60 min) free-field locomotor hypoactivity caused by nicotine (0.5 mg kg-1, i.m.), enhanced the later (60-120 min) nicotine-induced hyperactivity, and raised spontaneous nocturnal activity. Lesions reduced the extent of immunohistological staining for choline acetyltransferase in the interpeduncular nucleus (p < 0.025), but not for tyrosine hydroxylase in the surrounding catecholaminergic A10 region.. We conclude that the interpeduncular nicotinic depression of locomotor nicotinic arousal mechanisms located elsewhere in the brain.

Original languageEnglish (US)
Pages (from-to)2469-2472
Number of pages4
JournalNeuroreport
Volume6
Issue number18
DOIs
StatePublished - Dec 1995

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Keywords

  • Acetylcholine
  • Arousal
  • Kainic acid
  • Mecamylamine
  • Midbrain
  • Nicotine

ASJC Scopus subject areas

  • Neuroscience(all)

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