The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus

Ian D. Hentall, Viju M. Budhrani

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.

Original languageEnglish (US)
Pages (from-to)322-324
Number of pages3
JournalBrain Research
Volume522
Issue number2
DOIs
StatePublished - Jul 9 1990

Keywords

  • Interpeduncular nucleus
  • Pain
  • Raphe magnus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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