Abstract
The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 322-324 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 522 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 9 1990 |
Keywords
- Interpeduncular nucleus
- Pain
- Raphe magnus
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Hentall, I. D., & Budhrani, V. M. (1990). The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus. Brain Research, 522(2), 322-324. https://doi.org/10.1016/0006-8993(90)91476-W