Abstract
The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
| Original language | English |
|---|---|
| Pages (from-to) | 322-324 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 522 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 9 1990 |
| Externally published | Yes |
Fingerprint
Keywords
- Interpeduncular nucleus
- Pain
- Raphe magnus
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus. / Hentall, Ian; Budhrani, Viju M.
In: Brain Research, Vol. 522, No. 2, 09.07.1990, p. 322-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus
AU - Hentall, Ian
AU - Budhrani, Viju M.
PY - 1990/7/9
Y1 - 1990/7/9
N2 - The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
AB - The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.
KW - Interpeduncular nucleus
KW - Pain
KW - Raphe magnus
UR - http://www.scopus.com/inward/record.url?scp=0024991827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024991827&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(90)91476-W
DO - 10.1016/0006-8993(90)91476-W
M3 - Article
C2 - 2224530
AN - SCOPUS:0024991827
VL - 522
SP - 322
EP - 324
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -