The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus

Ian Hentall, Viju M. Budhrani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cells (92%) were found to be inhibited by IPN stimulation, whereas on-cells (50%) were excited. Based on previously suggested roles for the NRM neurons, we argue that both effects are hyperalgetic.

Original languageEnglish
Pages (from-to)322-324
Number of pages3
JournalBrain Research
Volume522
Issue number2
DOIs
StatePublished - Jul 9 1990
Externally publishedYes

Fingerprint

Cell Nucleus
Pentobarbital
Nucleus Raphe Magnus
Interpeduncular Nucleus
Anesthesia
Neurons
Skin

Keywords

  • Interpeduncular nucleus
  • Pain
  • Raphe magnus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus. / Hentall, Ian; Budhrani, Viju M.

In: Brain Research, Vol. 522, No. 2, 09.07.1990, p. 322-324.

Research output: Contribution to journalArticle

Hentall, Ian ; Budhrani, Viju M. / The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus. In: Brain Research. 1990 ; Vol. 522, No. 2. pp. 322-324.
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