The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling

Silvia Bulfone-Paus, Elena Bulanova, Vadim Budagian, Ralf Paus

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Interleukin-15 (IL-15) is a pleiotropic cytokine of the 4 α-helix bundle family, which binds to a receptor complex that displays common elements with the IL-2 receptor and a unique high-affinity α chain. This review focuses on juxtacrine and reverse signaling levels in the IL-15/IL-15R system. Specifically, we discuss how agonistic stimulation of membrane-bound IL-15 induces phosphorylation of members of the MAP kinase family and of focal adhesion kinase (FAK), thereby upregulating processes including cytokine secretion, cell adhesion and migration. In addition, we explore IL-15 trans-presentation and intracellular signaling, and define promising molecular targets for future pharmacological intervention in infectious diseases and immunological disorders. These frontiers in IL-15/IL-15Rα research serve as highly instructive examples for key concepts, unsolved problems and therapeutic opportunities in juxtacrine and reverse signaling in general.

Original languageEnglish (US)
Pages (from-to)362-377
Number of pages16
JournalBioEssays
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2006

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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