The interface of depression and cardiovascular disease: Therapeutic implications

Fred Seligman, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Patients with major depression are at an increased risk for developing cardiovascular disease, respond more poorly to treatment, and exhibit worse outcomes, including increased morbidity and mortality. This article reviews the relationship between depression and heart disease, with an emphasis on epidemiology, biological substrates that likely underlie this relationship, and implications for treatment.

Original languageEnglish (US)
Pages (from-to)25-35
Number of pages11
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - 2015


  • Antidepressants
  • Cardiovascular disease
  • Depression
  • Mood disorders
  • Platelets

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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