The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression

Derick E. Vergne, Charles B. Nemeroff

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Considerable literature supports the hypothesis of dysfunction in central nervous system serotonergic circuits in the pathophysiology of mood disorders, specifically major depression. Since the development of the selective serotonin (5-HT) reuptake inhibitors, a putative role for the 5-HT transporter (SERT) in the etiology of depression has been explored. The discovery of a functional SERT polymorphism has provided a novel tool to further scrutinize the role of serotonergic neurons in depression. This article reviews the burgeoning evidence of an interaction between early life stress and an SERT polymorphism on vulnerability to depression.

Original languageEnglish (US)
Pages (from-to)452-457
Number of pages6
JournalCurrent psychiatry reports
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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