The insulin gene in type 1 diabetes

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Insulin is a key autoantigen in the autoimmune process leading to the development of type 1 diabetes. Recent studies in both humans and mice have shown that variation in the expression of the insulin gene, in the thymus rather than the pancreas, contributes to disease susceptibility by affecting self-tolerance to insulin. These findings have brought about a paradigm-shift in our understanding of self-tolerance and autoimmunity to molecules with tissue-restricted expression, which are often the target of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)463-468
Number of pages6
JournalIUBMB life
Volume57
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • IDDM
  • IDDM2
  • Imprinting
  • INS
  • Insulin
  • Tolerance
  • Type 1 diabetes
  • VNTR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'The insulin gene in type 1 diabetes'. Together they form a unique fingerprint.

  • Cite this