The insulin gene in type 1 diabetes

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Insulin is a key autoantigen in the autoimmune process leading to the development of type 1 diabetes. Recent studies in both humans and mice have shown that variation in the expression of the insulin gene, in the thymus rather than the pancreas, contributes to disease susceptibility by affecting self-tolerance to insulin. These findings have brought about a paradigm-shift in our understanding of self-tolerance and autoimmunity to molecules with tissue-restricted expression, which are often the target of autoimmune disease.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalIUBMB Life
Volume57
Issue number7
DOIs
StatePublished - Jul 1 2005

Fingerprint

Medical problems
Type 1 Diabetes Mellitus
Self Tolerance
Genes
Insulin
Thymus
Disease Susceptibility
Autoantigens
Autoimmunity
Thymus Gland
Autoimmune Diseases
Pancreas
Tissue
Gene Expression
Molecules

Keywords

  • IDDM
  • IDDM2
  • Imprinting
  • INS
  • Insulin
  • Tolerance
  • Type 1 diabetes
  • VNTR

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

The insulin gene in type 1 diabetes. / Pugliese, Alberto.

In: IUBMB Life, Vol. 57, No. 7, 01.07.2005, p. 463-468.

Research output: Contribution to journalArticle

Pugliese, Alberto. / The insulin gene in type 1 diabetes. In: IUBMB Life. 2005 ; Vol. 57, No. 7. pp. 463-468.
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