The initation of glycogen biosynthesis in rat heart

Marta L. BLUMENFELD, William J. WHELAN, Clara R. KRISMAN

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A rat heart extract synthesizes glycogen-like material from UDP-glucose in the absence of added primer. Most of this material is precipitable by dilute trichloroacetic acid, in contrast to glycogen synthesized in presence of added glycogen primer. It is postulated that the endogenous initiation of glycogen synthesis occurs by apposition of glucose residues to a protein and that the material so synthesized in vitro corresponds to the protein-bound glycogen reported to exist in rat heart. The ability to label the putative protein primer in vitro with [14C]glucose should assist the isolation of the primer and the elucidation of the nature of the association between the carbohydrate and protein moeities.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalEuropean Journal of Biochemistry
Volume135
Issue number1
DOIs
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Biochemistry

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