The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Cancer Research