The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro

G. Fountzilas, L. O. Lim, A. A. Yunis

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalAnticancer research
Volume8
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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