The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro

G. Fountzilas; L. O. Lim; A. A. Yunis

The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro

G. Fountzilas, L. O. Lim, A. A. Yunis

Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID₅₀ of VM-26 and HHT was 6 x 10^-7 M and 2 x 10^-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID₅₀ for VM-26 and a 2,000-fold decrease for HHT. ¹⁴C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.

Original language	English (US)
Pages (from-to)	343-346
Number of pages	4
Journal	Anticancer research
Volume	8
Issue number	3
State	Published - Jan 1 1988

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.",

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T1 - The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro

AU - Fountzilas, G.

AU - Lim, L. O.

AU - Yunis, A. A.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.

AB - The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.

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