Abstract
The inhibitory effect of VM-26 and Homoharringtonine (HHT) on the in vitro growth of a human pancreatic cell line (MIA PaCa-2) was tested. The ID50 of VM-26 and HHT was 6 x 10-7 M and 2 x 10-5 M respectively. Increasing time exposure from 1 hr to continuous exposure for 5 days resulted in a 30-fold decrease in ID50 for VM-26 and a 2,000-fold decrease for HHT. 14C-labelled thymidine and leucine studies revealed that VM-26 inhibited DNA synthesis, while HTT inhibited both DNA and protein synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-346 |
| Number of pages | 4 |
| Journal | Anticancer research |
| Volume | 8 |
| Issue number | 3 |
| State | Published - Jan 1 1988 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Fountzilas, G., Lim, L. O., & Yunis, A. A. (1988). The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro. Anticancer research, 8(3), 343-346.