Abstract
At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
Original language | English (US) |
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Pages (from-to) | 175-182 |
Number of pages | 8 |
Journal | Research Communications in Chemical Pathology and Pharmacology |
Volume | 27 |
Issue number | 1 |
State | Published - Jan 1 1980 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)