Abstract
At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 27 |
| Issue number | 1 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). / Allen, L.; Meck, R.; Yunis, Adel A.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 27, No. 1, 1980, p. 175-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)
AU - Allen, L.
AU - Meck, R.
AU - Yunis, Adel A
PY - 1980
Y1 - 1980
N2 - At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
AB - At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
UR - http://www.scopus.com/inward/record.url?scp=0018891998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018891998&partnerID=8YFLogxK
M3 - Article
C2 - 6102405
AN - SCOPUS:0018891998
VL - 27
SP - 175
EP - 182
JO - Research Communications in Molecular Pathology and Pharmacology
JF - Research Communications in Molecular Pathology and Pharmacology
SN - 0034-5164
IS - 1
ER -