The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

L. Allen, R. Meck, A. Yunis

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.

Original languageEnglish (US)
Pages (from-to)175-182
Number of pages8
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume27
Issue number1
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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