At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
|Original language||English (US)|
|Number of pages||8|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Jan 1 1980|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)