Abstract
At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 27 |
| Issue number | 1 |
| State | Published - Jan 1 1980 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Allen, L., Meck, R., & Yunis, A. (1980). The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). Research Communications in Chemical Pathology and Pharmacology, 27(1), 175-182.