The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

L. Allen; R. Meck; A. Yunis

The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

L. Allen, R. Meck, A. Yunis

Medicine

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/10⁶ cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.

Original language	English (US)
Pages (from-to)	175-182
Number of pages	8
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	27
Issue number	1
State	Published - Jan 1 1980

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). / Allen, L.; Meck, R.; Yunis, A.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 27, No. 1, 01.01.1980, p. 175-182.

Research output: Contribution to journal › Article › peer-review

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abstract = "At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.",

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The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

Abstract

ASJC Scopus subject areas

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