The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

L. Allen; R. Meck; A. Yunis

The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

L. Allen, R. Meck, A. Yunis

Medicine

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/10⁶ cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.

Original language	English (US)
Pages (from-to)	175-182
Number of pages	8
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	27
Issue number	1
State	Published - Jan 1 1980

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). / Allen, L.; Meck, R.; Yunis, A.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 27, No. 1, 01.01.1980, p. 175-182.

Research output: Contribution to journal › Article › peer-review

@article{2b56a0901bd0406db6654aea0c4be444,

title = "The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)",

abstract = "At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.",

author = "L. Allen and R. Meck and A. Yunis",

year = "1980",

month = jan,

day = "1",

language = "English (US)",

volume = "27",

pages = "175--182",

journal = "Research Communications in Molecular Pathology and Pharmacology",

issn = "0034-5164",

publisher = "PJD Publications Ltd",

number = "1",

}

TY - JOUR

T1 - The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

AU - Allen, L.

AU - Meck, R.

AU - Yunis, A.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.

AB - At - 125, (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, at a concentration of 5 μM was found to inhibit the growth of human pancreatic carcinoma cells (MIA PaCa-2) by 78% after 72 hours in continuous culture. It was found that MIA PaCa-2 γ-glutmyl transpeptidase (10 nmol/min/106 cells) was irreversibly inactivated by AT-125 with an inactivation half-life of 80 minutes at 450 μM.

UR - http://www.scopus.com/inward/record.url?scp=0018891998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018891998&partnerID=8YFLogxK

M3 - Article

C2 - 6102405

AN - SCOPUS:0018891998

VL - 27

SP - 175

EP - 182

JO - Research Communications in Molecular Pathology and Pharmacology

JF - Research Communications in Molecular Pathology and Pharmacology

SN - 0034-5164

IS - 1

ER -

The inhibition of γ-glutamyl transpeptidase from human pancreatic carcinoma cells by (αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this