Abstract
Background. Glomerulosclerosis, the common terminal event in chronic glomerular diseases such as diabetic nephropathy or IgA nephropathy, leads to end-stage renal disease. The considerable variation in both the risk of developing glomerulosclerosis and the rate of progression in individual patients suggest a role for genetic factors which have not been identified so far. In this study we sought to examine the mode of inheritance of glomerulosclerosis in mice. Methods. F1 animals of a mating between glomerulosclerosis-prone ROP-Os/+ male and non-sclerotic C3H female mice were backcrossed to the ROP strain. We took advantage of the radiation-induced mutation oligosyndactylism (Os) to identify glomerulosclerosis at the age of 3 months. Kidneys were perfused in situ with PBS/Formalin 10%. The extent of glomerulosclerotic lesions was evaluated on PAS stained paraffin sections using computer-aided morphometry. Results. F1 mice did not show any glomerulosclerosis. In the backcross offspring, we found a wide distribution of glomerular lesions between individual animals, ranging from normal to very severe. We calculated that at least 8-10 loci determine the severity of glomerulosclerosis in mice. Conclusions. Our data show that glomerulosclerosis is inherited in a recessive fashion involving at least 8-10 loci.
Original language | English (US) |
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Pages (from-to) | 3074-3078 |
Number of pages | 5 |
Journal | Nephrology Dialysis Transplantation |
Volume | 13 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1998 |
Externally published | Yes |
Keywords
- Genetics
- Glomerulosclerosis
- Mice
- Oligosyndactyly
ASJC Scopus subject areas
- Nephrology
- Transplantation